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CD20 antibodies induce production and release of reactive oxygen species by neutrophils.

作者信息

Werlenius Olle, Riise Rebecca E, Simpanen Maria, Aurelius Johan, Thorén Fredrik B

机构信息

Sahlgrenska Cancer Center and Department of Hematology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Sahlgrenska Cancer Center and Department of Infectious Diseases, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

出版信息

Blood. 2014 Jun 19;123(25):4001-2. doi: 10.1182/blood-2014-05-574285.

DOI:10.1182/blood-2014-05-574285
PMID:24948624
Abstract
摘要

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Reactive oxygen species induced by therapeutic CD20 antibodies inhibit natural killer cell-mediated antibody-dependent cellular cytotoxicity against primary CLL cells.治疗性CD20抗体诱导产生的活性氧抑制自然杀伤细胞介导的针对原发性慢性淋巴细胞白血病细胞的抗体依赖性细胞毒性作用。
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