Schippling S, Balk L J, Costello F, Albrecht P, Balcer L, Calabresi P A, Frederiksen J L, Frohman E, Green A J, Klistorner A, Outteryck O, Paul F, Plant G T, Traber G, Vermersch P, Villoslada P, Wolf S, Petzold A
Neuroimmunology and MS Research Section, University Hospital Zurich, Switzerland.
MS Centre Amsterdam, VU University Medical Centre, The Netherlands.
Mult Scler. 2015 Feb;21(2):163-70. doi: 10.1177/1352458514538110. Epub 2014 Jun 16.
Retinal optical coherence tomography (OCT) permits quantification of retinal layer atrophy relevant to assessment of neurodegeneration in multiple sclerosis (MS). Measurement artefacts may limit the use of OCT to MS research.
An expert task force convened with the aim to provide guidance on the use of validated quality control (QC) criteria for the use of OCT in MS research and clinical trials.
A prospective multi-centre (n = 13) study. Peripapillary ring scan QC rating of an OCT training set (n = 50) was followed by a test set (n = 50). Inter-rater agreement was calculated using kappa statistics. Results were discussed at a round table after the assessment had taken place.
The inter-rater QC agreement was substantial (kappa = 0.7). Disagreement was found highest for judging signal strength (kappa = 0.40). Future steps to resolve these issues were discussed.
Substantial agreement for QC assessment was achieved with aid of the OSCAR-IB criteria. The task force has developed a website for free online training and QC certification. The criteria may prove useful for future research and trials in MS using OCT as a secondary outcome measure in a multi-centre setting.
视网膜光学相干断层扫描（OCT）能够对与多发性硬化症（MS）神经退行性变评估相关的视网膜层萎缩进行量化。测量伪影可能会限制OCT在MS研究中的应用。
召集一个专家工作组，旨在为在MS研究和临床试验中使用OCT时采用经过验证的质量控制（QC）标准提供指导。
一项前瞻性多中心（n = 13）研究。先对一个OCT训练集（n = 50）进行视乳头周围环形扫描QC评级，然后对一个测试集（n = 50）进行评级。使用kappa统计量计算评分者间的一致性。评估完成后在一次圆桌会议上讨论了结果。
评分者间的QC一致性较高（kappa = 0.7）。在判断信号强度方面发现的分歧最大（kappa = 0.40）。讨论了解决这些问题的后续步骤。
借助OSCAR - IB标准在QC评估方面达成了较高的一致性。该工作组创建了一个网站用于免费在线培训和QC认证。这些标准可能对未来在多中心环境中使用OCT作为次要结局指标的MS研究和试验有用。
