谷胱甘肽硫转移酶T1（GSTT1）和谷胱甘肽硫转移酶M1（GSTM1）基因多态性与血压的关联：连续数据的贝叶斯建模
Association of GSTT1 and GSTM1 polymorphisms with blood pressure: A Bayesian modeling of continuous data.
作者信息
Rafee Laleh, Abedini Mahsa, Javanmard Shaghayegh Haghjooy, Sarrafzadegan Nizal, Mansourian Marjan
机构信息
Applied Physiology Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.
School of Statistics and Mathematics, University of Isfahan, Isfahan, Iran.
出版信息
J Res Med Sci. 2014 Mar;19(3):200-4.
BACKGROUND
Systolic blood pressure (SBP) and diastolic blood pressure (DBP) are a multi-factorial traits and significantly heritable. Glutathione S-transferase (GST) enzyme is involved in detoxification of reactive oxygen species. The present study aimed at finding out the association between GSTM1 and GSTT1 polymorphisms and mean arterial pressure (MAP) in Iranian population. MAP, as the important indicator of blood pressure, is calculated by weighted averaging of SBP and DBP.
MATERIALS AND METHODS
we randomly selected 72 healthy individuals from Isfahan Cohort Study (ICS). Polymerase chain reaction (PCR) was done to detect polymorphism of the GSTM1 and GSTT1 genes. The Bayesian Structured Regression model was used, adjusted for sex, age, body mass index (BMI), and smoking status.
RESULTS
The results showed that both the GSTT1and GSTM1genotypes deletion had a significant effect on MAP increasing in our samples based on 95% Bayesian credible intervals.
CONCLUSION
This study demonstrated that GSTT1 and GSTM1 gene increase the arterial pressure; hence, it can predict the susceptibility to cardiovascular disease.
背景
收缩压（SBP）和舒张压（DBP）是多因素性状，具有显著的遗传性。谷胱甘肽S-转移酶（GST）参与活性氧的解毒过程。本研究旨在探讨伊朗人群中GSTM1和GSTT1基因多态性与平均动脉压（MAP）之间的关联。MAP作为血压的重要指标，通过SBP和DBP的加权平均值计算得出。
材料与方法
我们从伊斯法罕队列研究（ICS）中随机选取了72名健康个体。采用聚合酶链反应（PCR）检测GSTM1和GSTT1基因的多态性。使用贝叶斯结构回归模型，并对性别、年龄、体重指数（BMI）和吸烟状况进行了校正。
结果
结果显示，基于95%的贝叶斯可信区间，GSTT1和GSTM1基因的缺失基因型对我们样本中的MAP升高有显著影响。
结论
本研究表明，GSTT1和GSTM1基因会升高动脉压，因此可以预测心血管疾病的易感性。
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