15-羟基前列腺素脱氢酶与胃腺癌之间的关系。

Relationship between 15-hydroxyprostaglandin dehydrogenase and gastric adenocarcinoma.

作者信息

Kang Jae Hyun, Kang Sang Hyun, Seo Sang Hyuk, Shin Jae Ho, An Min Sung, Ha Tae Kwun, Bae Ki Beom, Kim Tae Hyun, Choi Chang Soo, Oh Sang Hoon, Kang Mi Seon, Kim Kwang Hee

机构信息

Department of Surgery, Inje University College of Medicine, Busan, Korea.

出版信息

Ann Surg Treat Res. 2014 Jun;86(6):302-8. doi: 10.4174/astr.2014.86.6.302. Epub 2014 May 23.

DOI:10.4174/astr.2014.86.6.302

PMID:24949321

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4062450/

Abstract

PURPOSE

Prostaglandin E2 (PGE2) is a contributory carcinogen in gastric adenocarcinoma. 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) catabolizes PGE2 by oxidizing its 15(s)-hydroxy group. The aim of this study was to investigate the expression of 15-PGDH in gastric adenocarcinoma tissue and the relationship between 15-PGDH expression and clinicopathologic features of gastric adenocarcinoma.

METHODS

Ninety-nine patients who underwent surgical resection for gastric adenocarcinoma between January 2007 and December 2007 were enrolled and evaluated retrospectively.

RESULTS

In 62 patients (62.6%), 15-PGDH expression was lower in gastric adenocarcinoma tissue than in nonneoplastic tissue. Regarding the relationship between 15-PGDH expression and clinicopathological features, 15-PGDH expression was significantly lower in tissues with poor differentiation (P = 0.002), advanced T stage (P = 0.0319), a higher number of lymph node metastases (P = 0.045), lymphatic invasion (P = 0.031), and vascular invasion (P = 0.036).

CONCLUSION

15-PGDH expression was associated with a subset of clinicopathologic features such as differentiation grade, T stage, lymphatic invasion, and vascular invasion.

摘要

目的

前列腺素E2（PGE2）是胃腺癌中的一种致癌因素。15-羟基前列腺素脱氢酶（15-PGDH）通过氧化PGE2的15（s）-羟基来分解代谢PGE2。本研究旨在探讨15-PGDH在胃腺癌组织中的表达情况以及15-PGDH表达与胃腺癌临床病理特征之间的关系。

方法

回顾性纳入并评估了2007年1月至2007年12月期间接受胃腺癌手术切除的99例患者。

结果

62例患者（62.6%）的胃腺癌组织中15-PGDH表达低于非肿瘤组织。关于15-PGDH表达与临床病理特征的关系，在分化差的组织（P = 0.002）、T分期较晚（P = 0.0319）、淋巴结转移数量较多（P = 0.045）、存在淋巴侵犯（P = 0.031）和血管侵犯（P = 0.036）的组织中，15-PGDH表达显著降低。