用于控制疼痛的血管紧张素 II 型 2 受体。
The angiotensin II type 2 receptor for pain control.
机构信息
Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, Rotterdam 3015 CN, The Netherlands.
Centre for Clinical Translation, Division of Brain Sciences, Imperial College London, London W12 0NN, UK.
出版信息
Cell. 2014 Jun 19;157(7):1504-6. doi: 10.1016/j.cell.2014.05.030.
All well-known deleterious effects of angiotensin (Ang) II, including vasoconstriction, inflammation, water and salt retention, and vascular remodeling, are mediated via its type 1 (AT1) receptor. This explains why AT1 receptor blockers (ARBs) and inhibitors of Ang II synthesis, such as ACE inhibitors and renin inhibitors, are beneficial for cardiovascular disease. Yet, Ang II has a second receptor, the Ang II type 2 (AT2) receptor, the function of which, even after over 20 years of research, remains largely unknown. In this issue, Marion et al. provide a new chapter to the AT2 receptor story.
血管紧张素（Ang）II 的所有广为人知的有害作用，包括血管收缩、炎症、水盐潴留和血管重塑，都是通过其 1 型（AT1）受体介导的。这就解释了为什么 AT1 受体阻滞剂（ARB）和 Ang II 合成抑制剂，如 ACE 抑制剂和肾素抑制剂，对心血管疾病有益。然而，Ang II 还有第二个受体，即 Ang II 型 2（AT2）受体，尽管已经研究了 20 多年，但它的功能在很大程度上仍然未知。在本期杂志中，Marion 等人为此提供了一个新的篇章。
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