Guy A J, Griffin S M, Alderson D, Farndon J R
Department of Surgery, Medical School, Framlington, University of Newcastle upon Tyne, UK.
Br J Surg. 1989 Feb;76(2):191-4. doi: 10.1002/bjs.1800760228.
Successful islet allografts can be established in rats bearing long surviving renal allografts, without additional immunosuppression, when kidney and islet donor animals are of the same strain. The applicability of such a scheme to clinical practice has been investigated in a large animal model of diabetes: the pancreatectomized dog. Eight dogs with previously established renal allografts and immunosuppressed with cyclosporin A received islet allografts from their respective original kidney donors. The median islet graft functional survival was only 10.5 days, significantly less than for six similarly immunosuppressed dogs receiving islet allografts alone (48.5 days, P less than 0.05). Three of the sequentially transplanted dogs had had no renal graft rejection episodes before islet transplantation, yet their islet grafts were all rejected within 19 days. In the pancreatectomized dog, prior donor specific renal transplantation has an adverse effect upon subsequent islet graft survival.
当肾脏和胰岛供体动物为同一品系时，在长期存活的肾移植大鼠中可不需额外免疫抑制就能成功建立胰岛同种异体移植。已在糖尿病大动物模型——胰腺切除犬中研究了该方案在临床实践中的适用性。8只先前已接受肾移植并用环孢素A免疫抑制的犬接受了来自其各自原肾脏供体的胰岛移植。胰岛移植功能存活的中位数仅为10.5天，显著短于6只同样接受免疫抑制但仅接受胰岛移植的犬（48.5天，P<0.05）。3只序贯移植的犬在胰岛移植前未发生肾移植排斥反应，但其胰岛移植均在19天内被排斥。在胰腺切除犬中，先前的供体特异性肾移植对随后的胰岛移植存活有不利影响。
