去甲肾上腺素耗竭对大鼠脑血流量的影响。

The effects of norepinephrine depletion on cerebral blood flow in the rat.

作者信息

Onesti S T, Strauss R C, Mayol B, Solomon R A

机构信息

Department of Neurological Surgery, Columbia University, College of Physicians and Surgeons, New York, NY.

出版信息

Brain Res. 1989 Jan 16;477(1-2):378-81. doi: 10.1016/0006-8993(89)91431-5.

DOI:10.1016/0006-8993(89)91431-5

PMID:2495151

Abstract

Cerebral blood flow (CBF) was measured by [14C]butanol indicator fractionation in 10 rats given intraventricular injections of 6-hydroxydopamine (6-OHDA) compared to 8 saline-injected controls. Rats treated with 6-OHDA displayed an 83% reduction in cortical norepinephrine (NE) levels. CBF was significantly increased in 6-OHDA-treated rats compared to controls (average whole brain blood flow of 126.0 +/- 8.3 and 97.1 +/- 10.6 ml.min-1.10(-2)g-1 respectively, P less than 0.05). These studies suggest that noradrenergic innervation of the brain and cerebral microvasculature exerts a moderating effect on resting CBF.

摘要

通过[14C]丁醇指示剂分级法，对10只经脑室内注射6-羟基多巴胺（6-OHDA）的大鼠和8只注射生理盐水的对照大鼠进行脑血流量（CBF）测量。用6-OHDA处理的大鼠皮质去甲肾上腺素（NE）水平降低了83%。与对照组相比，6-OHDA处理的大鼠CBF显著增加（全脑平均血流量分别为126.0±8.3和97.1±10.6 ml·min-1·10(-2)g-1，P<0.05）。这些研究表明，大脑和脑微血管的去甲肾上腺素能神经支配对静息CBF具有调节作用。