体重指数与胃癌风险：一项荟萃分析。

Body mass index and risk of gastric cancer: a meta-analysis.

机构信息

Epidemiology and Statistics, School of Public Health, Jilin University, Changchun.

School of Mathematics and Statistics, Northeast Normal University, Changchun.

出版信息

Jpn J Clin Oncol. 2014 Sep;44(9):783-91. doi: 10.1093/jjco/hyu082. Epub 2014 Jun 20.

DOI:10.1093/jjco/hyu082

PMID:24951830

Abstract

OBJECTIVE

Overweight and obesity, indicated as increased body mass index, are associated with the risk of some cancers. We carried out a meta-analysis on published cohort and case-control studies to assess the strength of association between body mass index and gastric cancer.

METHODS

Relevant studies were identified through PubMed, Web of Science and Medline electronic databases. Adjusted relative risks (odds ratios) with 95% confidence interval were used to assess the strength of association between body mass index and gastric cancer.

RESULTS

Sixteen eligible studies were included in this meta-analysis. Overall, obesity (body mass index ≥ 30 kg/m(2)) was associated with an increased risk of gastric cancer (odds ratio = 1.13, 95% confidence interval = 1.03-1.24) compared with normal weight (body mass index = 18.5 to <25 kg/m(2)), while overweight (body mass index = 18.5 to <30 kg/m(2)) showed no association (odds ratio = 1.04, 95% confidence interval = 0.96-1.12). Specifically, a stratified analysis showed there were associations between obesity and the increased risk of gastric cancer for males (odds ratio = 1.27, 95% confidence interval = 1.09-1.48), non-Asians (odds ratio = 1.14, 95% confidence interval = 1.02-1.28) and both cohort studies (odds ratio = 1.10, 95% confidence interval = 1.00-1.22) and case-control studies (odds ratio = 1.29, 95% confidence interval = 1.03-1.60). Both overweight (odds ratio = 1.22, 95% confidence interval = 1.05-1.42) and obesity (odds ratio = 1.61, 95% confidence interval = 1.15-2.24) were associated with the increased risk of gastric cardia cancer.

CONCLUSIONS

The results indicated that obesity was associated with the risk of gastric cancer, especially for males and among non-Asians. Both overweight and obesity were associated with the risk of gastric cardia cancer.

摘要

目的

超重和肥胖（以体重指数增加表示）与某些癌症的风险相关。我们对已发表的队列研究和病例对照研究进行了荟萃分析，以评估体重指数与胃癌之间的关联强度。

方法

通过 PubMed、Web of Science 和 Medline 电子数据库确定相关研究。使用调整后的相对风险（比值比）及其 95%置信区间来评估体重指数与胃癌之间的关联强度。

结果

本荟萃分析纳入了 16 项符合条件的研究。总体而言，与正常体重（体重指数为 18.5 至 <25 kg/m²）相比，肥胖（体重指数≥30 kg/m²）与胃癌风险增加相关（比值比=1.13，95%置信区间=1.03-1.24），而超重（体重指数为 18.5 至 <30 kg/m²）则无关联（比值比=1.04，95%置信区间=0.96-1.12）。具体而言，分层分析显示，肥胖与男性（比值比=1.27，95%置信区间=1.09-1.48）、非亚洲人（比值比=1.14，95%置信区间=1.02-1.28）以及队列研究（比值比=1.10，95%置信区间=1.00-1.22）和病例对照研究（比值比=1.29，95%置信区间=1.03-1.60）中胃癌风险增加相关。超重（比值比=1.22，95%置信区间=1.05-1.42）和肥胖（比值比=1.61，95%置信区间=1.15-2.24）均与贲门胃癌风险增加相关。