Harrison Patrick L, Abdel-Rahman Mohamed A, Miller Keith, Strong Peter N
Biomedical Research Centre, Biosciences Division, Sheffield Hallam University, Sheffield S1 1WB, UK.
Biomedical Research Centre, Biosciences Division, Sheffield Hallam University, Sheffield S1 1WB, UK; Zoology Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt.
Toxicon. 2014 Sep;88:115-37. doi: 10.1016/j.toxicon.2014.06.006. Epub 2014 Jun 19.
The need for new antimicrobial agents is becoming one of the most urgent requirements in modern medicine. The venoms of many different species are rich sources of biologically active components and various therapeutic agents have been characterized including antimicrobial peptides (AMPs). Due to their potent activity, low resistance rates and unique mode of action, AMPs have recently received much attention. This review focuses on AMPs from the venoms of scorpions and examines all classes of AMPs found to date. It gives details of their biological activities with reference to peptide structure. The review examines the mechanism of action of AMPs and with this information, suggests possible mechanisms of action of less well characterised peptides. Finally, the review examines current and future trends of scorpion AMP research, by discussing recent successes obtained through proteomic and transcriptomic approaches.
新型抗菌药物的需求正成为现代医学中最迫切的需求之一。许多不同物种的毒液富含生物活性成分，并且已经鉴定出各种治疗剂，包括抗菌肽（AMPs）。由于其强大的活性、低耐药率和独特的作用方式，抗菌肽最近受到了广泛关注。这篇综述聚焦于蝎子毒液中的抗菌肽，并研究了迄今为止发现的所有抗菌肽类别。它结合肽结构详细介绍了它们的生物活性。该综述研究了抗菌肽的作用机制，并基于此信息推测了特征尚不明确的肽可能的作用机制。最后，通过讨论蛋白质组学和转录组学方法近期取得的成功，该综述探讨了蝎子抗菌肽研究的当前和未来趋势。
