Grant R, Condon B, Patterson J, Wyper D J, Hadley M D, Teasdale G M
University Department of Neurosurgery, Glasgow, Scotland, UK.
J Neurol Neurosurg Psychiatry. 1989 Feb;52(2):218-22. doi: 10.1136/jnnp.52.2.218.
Magnetic resonance imaging was used to measure the effect of inhalation of 7% CO2 and hyperventilation with 60% O2 on human cranial cerebrospinal fluid volume. During CO2 inhalation there was a reduction in the cranial CSF volume ranging from 0.7-23.7 ml (mean 9.36 ml). The degree of reduction in cranial CSF volume was independent of the individual subject's increase in end-expiratory pCO2 or mean arterial blood pressure, in response to hypercapnia. During hyperventilation with high concentration oxygen the cranial CSF volume increased in all subjects (range 0.7-26.7 ml, mean 12.7 ml). The mean changes in cranial CSF volume, induced by hypercapnia and hypocapnia, were very similar to the expected reciprocal changes in cerebral blood volume.
采用磁共振成像技术测量吸入7%二氧化碳和用60%氧气进行过度通气对人体颅腔脑脊液容量的影响。吸入二氧化碳期间，颅腔脑脊液容量减少0.7 - 23.7毫升（平均9.36毫升）。颅腔脑脊液容量减少的程度与个体受试者因高碳酸血症导致的呼气末二氧化碳分压升高或平均动脉血压升高无关。在高浓度氧气过度通气期间，所有受试者的颅腔脑脊液容量均增加（范围为0.7 - 26.7毫升，平均12.7毫升）。高碳酸血症和低碳酸血症引起的颅腔脑脊液容量平均变化与预期的脑血容量反向变化非常相似。
