Kong Qiu-Huan, Wang Yu, Song Chen-Ge, Liu Yu-Shan, Qin Hui-Ying, Feng Yan-Dan, Li Ya-Jun
Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China; State Key Laboratory of Oncology in South China, Guangzhou, China.
Department of Lymphoma and Hematology, Hunan Provincial Tumor Hospital, Changsha, Hunan, China; The Affiliated Tumor Hospital of Xiangya Medical School, Central South University, Changsha, Hunan, China.
Eur J Oncol Nurs. 2014 Oct;18(5):540-4. doi: 10.1016/j.ejon.2014.03.016. Epub 2014 Jun 20.
To explore the risk factors for falls in lymphoma patients receiving chemotherapy.
Lymphoma patients (203) who received chemotherapy were prospectively recruited and analyzed. Eligible participants were followed up by weekly telephone contact for 6 months or until the time of a fall or death. Risk factors for falling in lymphoma patients were identified using univariate regression analysis and multivariate binary logistic regression analysis.
Of the 203 cases, 13.3% (27 cases) had a fall during follow-up. Univariate regression analysis showed the following risk factors for falls in lymphoma patients: gender (P = 0.023), Eastern Cooperative Oncology Group (ECOG) performance status score (P < 0.0001), cancer stage (P < 0.0001), extranodal involvement (P = 0.041), serum lactate dehydrogenase (LDH) level (P < 0.0001), revised International Prognostic Index (R-IPI) (P < 0.0001), history of falls (P < 0.0001), gait (P < 0.0001), cognitive condition (P = 0.029) and intravenous catheter placement (P < 0.0001). Multivariate binary logistic regression analysis found four independent factors significantly associated with the risk of falling in lymphoma patients: female gender (P = 0.042), later stage (P = 0.021), R-IPI (P = 0.030), and intravenous catheter placement (P = 0.001).
Gender, stage, R-IPI, and intravenous catheter placement were independent risk factors for falls in patients with lymphoma. Lymphoma patients with these four risk factors should receive particular attention and fall prevention education to reduce the incidence of falls. The R-IPI may be a new predictor of falling in lymphoma patients and may aid in the management of falls.
探讨接受化疗的淋巴瘤患者发生跌倒的危险因素。
前瞻性招募并分析203例接受化疗的淋巴瘤患者。符合条件的参与者通过每周电话随访6个月，或直至发生跌倒或死亡。采用单因素回归分析和多因素二元逻辑回归分析确定淋巴瘤患者跌倒的危险因素。
203例患者中，13.3%（27例）在随访期间发生跌倒。单因素回归分析显示淋巴瘤患者跌倒的危险因素如下：性别（P = 0.023）、东部肿瘤协作组（ECOG）体能状态评分（P < 0.0001）、癌症分期（P < 0.0001）、结外受累（P = 0.041）、血清乳酸脱氢酶（LDH）水平（P < 0.0001）、修订的国际预后指数（R-IPI）（P < 0.0001）、跌倒史（P < 0.0001）、步态（P < 0.0001）、认知状况（P = 0.029）和静脉置管（P < 0.0001）。多因素二元逻辑回归分析发现与淋巴瘤患者跌倒风险显著相关的四个独立因素：女性（P = 0.042）、晚期（P = 0.021）、R-IPI（P = 0.030）和静脉置管（P = 0.001）。
性别、分期、R-IPI和静脉置管是淋巴瘤患者跌倒的独立危险因素。具有这四个危险因素的淋巴瘤患者应受到特别关注并接受跌倒预防教育，以降低跌倒发生率。R-IPI可能是淋巴瘤患者跌倒的一个新的预测指标，并可能有助于跌倒的管理。
