de Solà-Morales Oriol, Riera Maribel
Institut Investigació Sanitària Pere Virgili (IISPV), Reus, España; Health Institute for Technology Transfer (HITT), Barcelona, España.
Endocrinol Nutr. 2014 Nov;61(9):486-92. doi: 10.1016/j.endonu.2014.04.006. Epub 2014 Jun 19.
Urea has been recently proposed for the management of hyponatremia linked to the syndrome of inappropriate secretion of ADH (SIADH). The objective of the study was to review the levels of evidence for treatment of hyponatremia associated with SIADH with urea. We performed a: systematic review of experimental trials and grading according to SIGN. No clinical trials were found. The 6 studies analysed had methodological limitations and were prone to biases. In conclusion, there is no evidence to support the efficacy of urea for the treatment of hyponatremia following SIADH.
最近有人提出使用尿素来治疗与抗利尿激素分泌失调综合征（SIADH）相关的低钠血症。本研究的目的是回顾使用尿素治疗SIADH相关性低钠血症的证据水平。我们进行了一项：根据苏格兰院校指南网络（SIGN）对实验性试验进行的系统评价和分级。未发现临床试验。所分析的6项研究存在方法学局限性且容易产生偏差。总之，没有证据支持尿素对SIADH后低钠血症的治疗效果。
