Ruuskanen O, Arola M, Putto-Laurila A, Mertsola J, Meurman O, Viljanen M K, Halonen P
Department of Pediatrics, University of Turku, Turku University Hospital, Finland.
Pediatr Infect Dis J. 1989 Feb;8(2):94-9.
We studied the association of acute otitis media with different respiratory virus infections in a pediatric department on the basis of epidemics between 1980 and 1985. Altogether 4524 cases of acute otitis media were diagnosed. The diagnosis was confirmed by tympanocentesis in 3332 ears. Respiratory virus infection was diagnosed during the same period in 989 patients by detecting viral antigen in nasopharyngeal mucus. There was a significant correlation between acute otitis media and respiratory virus epidemics, especially respiratory syncytial virus epidemics. There was no significant correlation between outbreaks of other respiratory viruses and acute otitis media. Acute otitis media was diagnosed in 57% of respiratory syncytial virus, 35% of influenza A virus, 33% of parainfluenza type 3 virus, 30% of adenovirus, 28% of parainfluenza type 1 virus, 18% of influenza B virus and 10% of parainfluenza type 2 virus infections. These observations show a clear association of respiratory virus infections with acute otitis media. In this study on hospitalized children Haemophilus influenzae strains were the most common bacteriologic pathogens in middle ear fluid, occurring in 19% of cases. Streptococcus pneumoniae was present in 16% and Branhamella catarrhalis in 7% of cases. There was no association between specific viruses and bacteria observed in this study.
在1980年至1985年期间，我们基于流行病情况在一个儿科部门研究了急性中耳炎与不同呼吸道病毒感染之间的关联。共诊断出4524例急性中耳炎病例。其中3332耳通过鼓膜穿刺术确诊。同期通过检测鼻咽黏液中的病毒抗原，在989名患者中诊断出呼吸道病毒感染。急性中耳炎与呼吸道病毒流行，尤其是呼吸道合胞病毒流行之间存在显著相关性。其他呼吸道病毒的爆发与急性中耳炎之间无显著相关性。在呼吸道合胞病毒感染患者中，57%被诊断为急性中耳炎；甲型流感病毒感染患者中，35%；副流感3型病毒感染患者中，33%；腺病毒感染患者中，30%；副流感1型病毒感染患者中，28%；乙型流感病毒感染患者中，18%；副流感2型病毒感染患者中，10%。这些观察结果表明呼吸道病毒感染与急性中耳炎之间存在明显关联。在这项针对住院儿童的研究中，流感嗜血杆菌菌株是中耳积液中最常见的细菌病原体，19%的病例中出现。肺炎链球菌在16%的病例中存在，卡他布兰汉菌在7%的病例中存在。本研究未观察到特定病毒与细菌之间的关联。
