从真菌小脆柄菇培养物中分离得到的五种新的愈创木烷型二萜类化合物。
Five New Guanacastane-Type Diterpenes from Cultures of the Fungus Psathyrella candolleana.
作者信息
Yin Xia, Feng Tao, Li Zheng-Hui, Leng Ying, Liu Ji-Kai
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 People's Republic of China ; University of Chinese Academy of Sciences, Beijing, 100049 People's Republic of China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 People's Republic of China.
出版信息
Nat Prod Bioprospect. 2014 Jun;4(3):149-55. doi: 10.1007/s13659-014-0020-8. Epub 2014 May 8.
Five new guanacastane-type diterpenes, named guanacastepenes P-T (1-5), were isolated from cultures of the fungus Psathyrella candolleana. Their structures were elucidated on the basis of extensive spectroscopic methods. All of the compounds were tested for their 11β-hydroxysteroid dehydrogenase (11β-HSD1) inhibitory activity. Compound 3 exhibited inhibitory activity against both human and mouse isozymes of 11β-HSD1 with IC50 values of 6.2 and 13.9 μM, respectively.
从真菌小脆柄菇（Psathyrella candolleana）的培养物中分离出了五种新的瓜纳卡斯塔烷型二萜类化合物，命名为瓜纳卡斯塔萜P - T（1 - 5）。基于广泛的光谱方法阐明了它们的结构。对所有化合物进行了11β - 羟基类固醇脱氢酶（11β - HSD1）抑制活性测试。化合物3对人源和小鼠源的11β - HSD1同工酶均表现出抑制活性，IC50值分别为6.2和13.9 μM。
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