多发性硬化症患者脑脊液中载脂蛋白E和磷脂转运蛋白活性降低；与脑磁共振成像及脑脊液脂质变量的关系
Cerebrospinal fluid apolipoprotein E and phospholipid transfer protein activity are reduced in multiple sclerosis; relationships with the brain MRI and CSF lipid variables.
作者信息
Vuletic Simona, Kennedy Hal, Albers John J, Killestein Joep, Vrenken Hugo, Lütjohann Dieter, Teunissen Charlotte E
机构信息
Northwest Lipid Metabolism and Diabetes Research Laboratories, 401 Queen Anne Ave N, University of Washington, Department of Medicine, Seattle, WA 98109, USA.
Department of Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
出版信息
Mult Scler Relat Disord. 2014 Jul 1;3(4):533-541. doi: 10.1016/j.msard.2014.01.004.
Apolipoprotein E (apoE), phospholipid transfer protein (PLTP) activity, lipids, total tau and beta amyloid 1-42 (Aβ) were measured in cerebrospinal fluid (CSF) from controls (n=38) and multiple sclerosis (MS) patients (n=91). ApoE and PLTP activity were significantly reduced in MS compared to non-inflammatory disease controls (NINDC; p<0.05). In NINDC and MS, apoE correlated with PLTP activity (r=0.399 and 0.591, respectively), Aβ (r= 0.609 and 0.483, respectively), and total tau (r=0.748 and 0.380, respectively; all p<0.05). CSF apoE and PLTP significantly contributed to the variance of the normalized brain volume (NBV) and T2 lesion volume in MS (p<0.001 and p<0.05, respectively). ApoE correlated with CSF cholesterol and 24-hydroxycholesterol in all groups; PLTP activity correlated with CSF cholesterol in controls (p<0.05).
在对照组（n = 38）和多发性硬化症（MS）患者（n = 91）的脑脊液（CSF）中测量了载脂蛋白E（apoE）、磷脂转运蛋白（PLTP）活性、脂质、总tau蛋白和β淀粉样蛋白1-42（Aβ）。与非炎性疾病对照组（NINDC）相比，MS患者的apoE和PLTP活性显著降低（p<0.05）。在NINDC和MS患者中，apoE与PLTP活性相关（分别为r = 0.399和0.591）、与Aβ相关（分别为r = 0.609和0.483）以及与总tau蛋白相关（分别为r = 0.748和0.380；所有p<0.05）。脑脊液apoE和PLTP显著影响MS患者标准化脑体积（NBV）和T2病变体积的差异（分别为p<0.001和p<0.05）。在所有组中，apoE与脑脊液胆固醇和24-羟基胆固醇相关；在对照组中，PLTP活性与脑脊液胆固醇相关（p<0.05）。
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