Department of Cell Biology, SUNY Downstate Health Sciences University, 450 Clarkson Ave, Brooklyn, NY, USA.
Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, People's Republic of China.
Curr Atheroscler Rep. 2021 Jan 26;23(3):9. doi: 10.1007/s11883-021-00907-6.
Phospholipid transfer protein (PLTP), a member of lipid transfer protein family, is an important protein involved in lipid metabolism in the circulation. This article reviews recent PLTP research progresses, involving lipoprotein metabolism and atherogenesis.
PLTP activity influences atherogenic and anti-atherogenic lipoprotein levels. Human serum PLTP activity is a risk factor for human cardiovascular disease and is an independent predictor of all-cause mortality. PLTP deficiency reduces VLDL and LDL levels and attenuates atherosclerosis in mouse models, while PLTP overexpression exerts an opposite effect. Both PLTP deficiency and overexpression result in reduction of HDL which has different size, inflammatory index, and lipid composition. Moreover, although both PLTP deficiency and overexpression reduce cholesterol efflux capacity, but this effect has no impact in macrophage reverse cholesterol transport in mice. Furthermore, PLTP activity is related with metabolic syndrome, thrombosis, and inflammation. PLTP could be target for the treatment of dyslipidemia and atherosclerosis, although some potential off-target effects should be noted.
磷脂转运蛋白（PLTP）是脂质转运蛋白家族的成员，是循环中参与脂代谢的重要蛋白。本文综述了 PLTP 的最新研究进展，涉及脂蛋白代谢和动脉粥样硬化形成。
PLTP 活性影响致动脉粥样硬化和抗动脉粥样硬化脂蛋白水平。人血清 PLTP 活性是人类心血管疾病的危险因素，是全因死亡率的独立预测因子。PLTP 缺乏可降低 VLDL 和 LDL 水平，并减轻小鼠动脉粥样硬化，而 PLTP 过表达则产生相反的效果。PLTP 缺乏和过表达均导致 HDL 减少，其大小、炎症指数和脂质组成不同。此外，尽管 PLTP 缺乏和过表达均降低胆固醇流出能力，但对小鼠巨噬细胞逆向胆固醇转运无影响。此外，PLTP 活性与代谢综合征、血栓形成和炎症有关。PLTP 可能是治疗血脂异常和动脉粥样硬化的靶点，但应注意一些潜在的脱靶效应。
