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微小RNA-222在非小细胞肺癌中的表达及其预后潜力

MicroRNA-222 expression and its prognostic potential in non-small cell lung cancer.

作者信息

Mao Kai-ping, Zhang Wei-na, Liang Xiao-min, Ma Yu-rong

机构信息

Department of Thoracic Surgery, Qingdao Municipal Hospital, No. 5 Donghai Middle Road, Qingdao 266071, China.

出版信息

ScientificWorldJournal. 2014;2014:908326. doi: 10.1155/2014/908326. Epub 2014 Apr 13.

DOI:10.1155/2014/908326
PMID:24955421
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4009118/
Abstract

Overexpression of miR-222 has been found in several types of cancers; however, the expression of miR-222 in non-small cell lung cancer (NSCLC) and its prognostic values are unclear. This study aimed to investigate whether the miR-222 expression level is related to clinicopathological factors and prognosis of NSCLC. Through a prospective study, 100 pairs of NSCLC tissues and adjacent normal tissues were examined by quantitative reverse-transcription polymerase chain reaction. The correlation between miR-222 expression and clinicopathological features was analyzed, and the significance of miR-222 as a prognostic factor and its relationship with survival were determined. Results showed that the expression levels of miR-222 were significantly elevated in the NSCLC tissue compared with that in adjacent normal tissue. In addition, Cox's proportional hazards model analysis confirmed that miR-222 high expression level was an independent predictor of poor prognosis. In conclusion, miR-222 overexpression is involved in the poor prognosis of NSCLC and can be used as a biomarker for selection of cases requiring especial attention.

摘要

在多种癌症中均发现有miR-222的过表达；然而，miR-222在非小细胞肺癌（NSCLC）中的表达情况及其预后价值尚不清楚。本研究旨在探讨miR-222表达水平是否与NSCLC的临床病理因素及预后相关。通过一项前瞻性研究，采用定量逆转录聚合酶链反应检测了100对NSCLC组织及癌旁正常组织。分析了miR-222表达与临床病理特征之间的相关性，并确定了miR-222作为预后因素的意义及其与生存的关系。结果显示，与癌旁正常组织相比，NSCLC组织中miR-222的表达水平显著升高。此外，Cox比例风险模型分析证实，miR-222高表达水平是预后不良的独立预测因素。总之，miR-222过表达与NSCLC的不良预后有关，可作为需要特别关注病例的生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e39e/4009118/992304d258c4/TSWJ2014-908326.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e39e/4009118/a7693da46883/TSWJ2014-908326.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e39e/4009118/992304d258c4/TSWJ2014-908326.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e39e/4009118/a7693da46883/TSWJ2014-908326.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e39e/4009118/992304d258c4/TSWJ2014-908326.002.jpg

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