转录因子与寡双链体结合的传输线模型分析——单核苷酸修饰效应的区分
Transmission line model analysis of transcription factors binding to oligoduplexes - differentiation of the effect of single nucleotide modifications.
作者信息
Rodrigues Rogério M M, de-Carvalho Jorge, Henriques Silvia F, Mira Nuno P, Sá-Correia Isabel, Ferreira Guilherme N M
机构信息
IBB-Institute for Biotechnology and Bioengineering, Centro de Biomedicina Molecular e Estrutural, Universidade do Algarve, 8005-139 Faro, Portugal.
出版信息
Analyst. 2014 Aug 21;139(16):3871-4. doi: 10.1039/c4an00709c.
Advanced impedance spectroscopy analysis based on the transmission line model (TLM) is explored as a novel QCM acoustic biosensing platform for the detection of the single point mutation effect on the binding of the transcription factors (TFs) to immobilized DNA oligoduplexes and the characterization of the protein-DNA mechanical properties.
基于传输线模型（TLM）的先进阻抗谱分析被探索作为一种新型的石英晶体微天平（QCM）声学生物传感平台，用于检测转录因子（TFs）与固定化DNA寡双链结合的单点突变效应以及蛋白质-DNA力学性质的表征。
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