Lundin N B, Niciu M J, Luckenbaugh D A, Ionescu D F, Richards E M, Vande Voort J L, Brutsche N E, Machado-Vieira R, Zarate C A
Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Intramural Research Program, Bethesda, MD.
Pharmacopsychiatry. 2014 Jul;47(4-5):141-4. doi: 10.1055/s-0034-1377042. Epub 2014 Jun 23.
Deficiencies in both vitamin B12 and folate have been associated with depression. Recently, higher baseline vitamin B12 levels were observed in individuals with bipolar depression who responded to the antidepressant ketamine at 7 days post-infusion. This study sought to -replicate this result by correlating peripheral vitamin levels with ketamine's antidepressant efficacy in bipolar depression and major depressive disorder (MDD).
Baseline vitamin B12 and folate levels were obtained in 49 inpatients with treatment-resistant MDD and 34 inpatients with treatment-resistant bipolar depression currently experiencing a major depressive episode. All subjects received a single intravenous ketamine infusion. Post-hoc Pearson correlations were performed between baseline vitamin B12 and folate levels, as well as antidepressant response assessed by percent change in Hamilton Depression Rating Scale (HDRS) scores from baseline to 230 min, 1 day, and 7 days post-infusion.
No significant correlation was observed between baseline vitamin B12 or folate and percent change in HDRS for any of the 3 time points in either MDD or bipolar depression.
Ketamine's antidepressant efficacy may occur independently of baseline peripheral vitamin levels.
维生素B12和叶酸缺乏均与抑郁症有关。最近，在输注氯胺酮7天后对该抗抑郁药有反应的双相抑郁症患者中观察到较高的基线维生素B12水平。本研究旨在通过将外周维生素水平与氯胺酮在双相抑郁症和重度抑郁症（MDD）中的抗抑郁疗效相关联来重复这一结果。
获取了49例难治性MDD住院患者和34例目前正经历重度抑郁发作的难治性双相抑郁症住院患者的基线维生素B12和叶酸水平。所有受试者均接受了单次静脉注射氯胺酮。在基线维生素B12和叶酸水平以及通过汉密尔顿抑郁量表（HDRS）评分从基线到输注后230分钟、1天和7天的变化百分比评估的抗抑郁反应之间进行事后Pearson相关性分析。
在MDD或双相抑郁症的任何一个时间点，基线维生素B12或叶酸与HDRS变化百分比之间均未观察到显著相关性。
氯胺酮的抗抑郁疗效可能独立于基线外周维生素水平而发生。
