Department Physiological Sciences, Stellenbosch University, Stellenbosch, Private Bag X1, Matieland 7602, South Africa.
Department Physiological Sciences, Stellenbosch University, Stellenbosch, Private Bag X1, Matieland 7602, South Africa.
J Ethnopharmacol. 2014 Sep 11;155(2):987-91. doi: 10.1016/j.jep.2014.06.033. Epub 2014 Jun 21.
Hoodia gordonii (family Apocynaceae) has become known globally for its claimed effect of appetite suppression. Despite a relatively large body of evidence of the plant׳s chemical make-up, peer-reviewed studies to provide scientific information on physiological effects of Hoodia gordonii are relatively sparse. The role of the pregnane glycoside P57-commonly accepted to be responsible for appetite suppression-has been questioned recently. Furthermore, a variety of physiological side-effects associated with consumption of the plant in extracted form questions its suitability for consumption. Although adverse effects have been described before, the relative abundance of non-peer-reviewed data originating from patent documents and lay publication for advertising, which specifically only focus on beneficial outcomes, skews the view of the risk-benefit-balance. Here we provide a review of peer-reviewed studies on the plant׳s physiological effects. Novel data from an in vivo rodent study further elucidate the benefit-to-risk ratio associated with consumption.
we conclude that although Hoodia gordonii seems to have a desired effect on appetite and weight loss, this effect may at least in part be a secondary symptom of the serious adverse effects that are associated with consumption of the high doses required to achieve therapeutic clinical effect.
霍麻 Gordonii (夹竹桃科) 已成为全球知名的其声称的食欲抑制作用。尽管有大量的证据表明植物的化学组成，同行评议的研究提供有关霍麻 Gordonii 的生理作用的科学信息相对较少。孕烷糖苷 P57 的作用 - 通常被认为是负责食欲抑制 - 最近受到质疑。此外，由于以提取形式消耗植物而引起的各种生理副作用质疑其食用的适宜性。尽管已经描述了不良反应，但非同行评议的数据主要来自专利文件和宣传用的通俗出版物，这些数据只关注有益的结果，这使得对风险 - 效益平衡的看法产生了偏差。在这里，我们提供了对植物生理作用的同行评议研究的综述。来自体内啮齿动物研究的新数据进一步阐明了与消耗相关的获益 - 风险比。
我们的结论是，尽管霍麻 Gordonii 似乎对食欲和体重减轻有理想的效果，但这种效果至少部分可能是与消耗高剂量相关的严重不良反应的继发症状，而这些剂量是实现治疗临床效果所必需的。
