从美孕宁A到Bcl-xL和Mcl-1抗凋亡蛋白双重抑制剂的合成。
From meiogynin A to the synthesis of dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins.
作者信息
Desrat S, Remeur C, Gény C, Rivière G, Colas C, Dumontet V, Birlirakis N, Iorga B I, Roussi F
机构信息
Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles (ICSN), CNRS UPR 2301, 1 av de la Terrasse, 91 198 Gif-sur-Yvette Cedex, France.
出版信息
Chem Commun (Camb). 2014 Aug 11;50(62):8593-6. doi: 10.1039/c4cc01830c.
PMID:24956071
Abstract
The synthesis of one of the most potent dual inhibitors of the anti-apoptotic proteins Bcl-xL and Mcl-1 is reported. This analogue of a natural sesquiterpenoid dimer meiogynin A was elaborated by a convergent asymmetric synthesis with 36% yield in ten steps.
摘要
据报道，一种抗凋亡蛋白Bcl-xL和Mcl-1的最强效双抑制剂已被合成。这种天然倍半萜二聚体美ogynin A的类似物是通过汇聚不对称合成法精心制备的，十步反应的产率为36%。
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