Bao Hui-Lan, Ye Shang-He, Lou Shi-Xian, Lu Xiao-Wen, Zhou Xiang-Feng
Zhongguo Zhong Yao Za Zhi. 2014 Mar;39(6):1128-31.
Study the serum level of HGF, Cys C and TGF-beta1 in type 2 diabetic nephropathy (DN), the infect of Pingshen decoction on those index. Selected 69 cases of 2 type DN and randomly divided into therapy group (36 cases) and control group (33 cases). The therapy group were treated with Pingshen decoction 1 dose/d, bid po. The control group were treated with NephritisShu tablet, 6 tablet, tid po. 8 weeks was a course. Before and after treatment, we examine the serum level of HGF, Cys C and TGF-beta1 by ELISA and immunonephelometry, and compare with 30 cases of healthy control group. The study demonstrates that before treatment, the serum level of HGF in both groups were significantly lower than healthy control group (P < 0.01), but Cys C, TGF-beta1 were significantly higher (P < 0.01). After treatment, the serum level of HGF of both groups were increased. The serum level of HGF of therapy group were significantly higher than of control group (P < 0.01), but the serum level of Cys C and TGF-beta1 were significantly lower than control group (P < 0.01). The serum level of HGF was correlated negatively with Cys C,TGF-beta1. In control group, the UAER, urine beta2-MG and quantity of 24-hour urine protein were significantly decreased after treatment (P < 0.01). The index of urine of therapy group were significantly lower than control group (P < 0.01). Results indicate that test of serum level of HGF and Cys C,TGF-beta1 of diabetic nephropathy have important clinical significance. Pingshen decoction can effectively intervene in the serum level of HGF and Cys C, TGF-beta1 and index of urine.
研究2型糖尿病肾病（DN）患者血清中肝细胞生长因子（HGF）、胱抑素C（Cys C）和转化生长因子β1（TGF-β1）的水平，以及平肾汤对这些指标的影响。选取69例2型DN患者，随机分为治疗组（36例）和对照组（33例）。治疗组给予平肾汤1剂/天，口服，每日2次。对照组给予肾炎舒片，6片，口服，每日3次。8周为一个疗程。治疗前后，采用酶联免疫吸附测定法（ELISA）和免疫比浊法检测血清中HGF、Cys C和TGF-β1的水平，并与30例健康对照组进行比较。研究表明，治疗前，两组患者血清HGF水平均显著低于健康对照组（P<0.01），而Cys C、TGF-β1水平显著高于健康对照组（P<0.01）。治疗后，两组患者血清HGF水平均升高。治疗组血清HGF水平显著高于对照组（P<0.01），而血清Cys C和TGF-β1水平显著低于对照组（P<0.01）。血清HGF水平与Cys C、TGF-β1呈负相关。对照组治疗后尿白蛋白排泄率（UAER）、尿β2-微球蛋白（β2-MG）及24小时尿蛋白定量均显著降低（P<0.01）。治疗组尿指标显著低于对照组（P<0.01）。结果表明，检测糖尿病肾病患者血清HGF、Cys C、TGF-β1水平具有重要临床意义。平肾汤可有效干预糖尿病肾病患者血清HGF、Cys C、TGF-β1水平及尿指标。
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