Institut für Chemie und Biochemie, Freie Universität Berlin, Takustraße 3, 14195 Berlin, Germany.
Chem Soc Rev. 2015 Jan 21;44(2):515-31. doi: 10.1039/c4cs00167b.
The remarkable technical advances in mass spectrometry during the last decades, including soft ionisation techniques, the coupling of electrospray ionisation to flow reactors, and the broad scope of tandem mass spectrometric experiments applicable to mass-selected ions allow investigating the chemistry of molecular capsules in solution as well as in the absence of any environment. With these methods, mass spectrometry is capable of answering many questions starting from providing analytical characterisation data (elemental composition, stoichiometry, etc.) to structural aspects (connectivities, positions of building blocks in supramolecular complexes) and to the examination of solution and gas-phase reactivity including reactions inside molecular containers. The present article reviews this work with a focus rather on the chemical questions that can be answered than on the technical specialities of (tandem) mass spectrometry.
过去几十年中，质谱技术取得了显著进展，包括软电离技术、电喷雾离子化与流动反应器的耦合，以及广泛适用于质量选择离子的串联质谱实验，这些都使得研究分子胶囊在溶液中和无任何环境下的化学性质成为可能。有了这些方法，质谱能够回答许多问题，从提供分析特性数据（元素组成、化学计量等）到结构方面（连接性、超分子配合物中构建块的位置），再到考察溶液和气相反应性，包括分子容器内的反应。本文综述了这方面的工作，重点关注可以回答的化学问题，而不是（串联）质谱技术的技术特点。
