脂质体布比卡因与布比卡因：比较性综述
Bupivacaine liposomal versus bupivacaine: comparative review.
作者信息
Noviasky John, Pierce Deirdre P, Whalen Karen, Guharoy Roy, Hildreth Kenneth
机构信息
Clinical Coordinator, Upstate University Hospital at Community General , Syracuse, New York.
Assistant Professor of Pharmacy Practice, St. John Fisher College, Wegmans School of Pharmacy , Rochester, New York.
出版信息
Hosp Pharm. 2014 Jun;49(6):539-43. doi: 10.1310/hpj4906-539.
Abstract
Bupivacaine liposomal injection was recently approved by the US Food and Drug Administration (FDA) as a local anesthetic for use in management of postsurgical pain in adults. When compared to placebo, bupivacaine liposomal decreases postoperative pain and opioid use. This review examines the efficacy of bupivacaine liposomal when compared to conventional bupivacaine ± epinephrine using published and unpublished data provided to the FDA by the manufacturer.
摘要
布比卡因脂质体注射液最近获得美国食品药品监督管理局（FDA）批准，作为一种局部麻醉剂用于成人术后疼痛管理。与安慰剂相比，布比卡因脂质体可减轻术后疼痛并减少阿片类药物的使用。本综述使用制造商提供给FDA的已发表和未发表数据，研究了布比卡因脂质体与传统布比卡因±肾上腺素相比的疗效。
相似文献
1
Bupivacaine liposomal versus bupivacaine: comparative review.脂质体布比卡因与布比卡因：比较性综述
Hosp Pharm. 2014 Jun;49(6):539-43. doi: 10.1310/hpj4906-539.
2
The Efficacy of Liposomal Bupivacaine for Opioid and Pain Reduction: A Systematic Review of Randomized Clinical Trials.脂质体布比卡因在减少阿片类药物和疼痛方面的疗效：随机临床试验的系统评价。
J Surg Res. 2021 Aug;264:510-533. doi: 10.1016/j.jss.2021.02.024. Epub 2021 Apr 13.
3
A Prospective, Randomized, Open-Label Study Comparing an Opioid-Sparing Postsurgical Pain Management Protocol With and Without Liposomal Bupivacaine for Full-Arch Implant Surgery.一项前瞻性、随机、开放标签研究，比较用于全牙弓种植手术的含与不含脂质体布比卡因的减少阿片类药物用量的术后疼痛管理方案。
Int J Oral Maxillofac Implants. 2018 Sep/Oct;33(5):1155-1164. doi: 10.11607/jomi.5938.
4
Liposomal Bupivacaine Injection Technique in Total Knee Arthroplasty.全膝关节置换术中脂质体布比卡因注射技术
J Knee Surg. 2017 Jan;30(1):88-96. doi: 10.1055/s-0036-1581133. Epub 2016 Apr 27.
5
Liposomal bupivacaine: an innovative nonopioid local analgesic for the management of postsurgical pain.脂质体布比卡因：一种新型非阿片类局部镇痛药，用于治疗术后疼痛。
Pharmacotherapy. 2012 Sep;32(9 Suppl):19S-26S. doi: 10.1002/j.1875-9114.2012.01183.x.
6
Liposomal Bupivacaine Versus Standard Periarticular Injection in Total Knee Arthroplasty With Regional Anesthesia: A Prospective Randomized Controlled Trial.局部麻醉下单髁膝关节置换术中脂质体布比卡因与关节周围注射标准局麻药的前瞻性随机对照研究。
J Arthroplasty. 2019 Mar;34(3):488-494. doi: 10.1016/j.arth.2018.11.026. Epub 2018 Nov 23.
7
Liposomal bupivacaine: a review of a new bupivacaine formulation.脂质体布比卡因：一种新型布比卡因制剂的综述。
J Pain Res. 2012;5:257-64. doi: 10.2147/JPR.S27894. Epub 2012 Aug 14.
8
Liposomal bupivacaine infiltration in the surgical site for analgesia after rotator cuff repair: a randomized, double-blinded, placebo-controlled trial.局部注射包载布比卡因的脂质体在肩袖修复术后镇痛中的应用：一项随机、双盲、安慰剂对照试验。
J Shoulder Elbow Surg. 2021 May;30(5):986-993. doi: 10.1016/j.jse.2020.10.035. Epub 2020 Dec 5.
9
No Difference in Early Analgesia Between Liposomal Bupivacaine Injection and Intrathecal Morphine After TKA.全膝关节置换术后脂质体布比卡因注射与鞘内注射吗啡在早期镇痛方面无差异。
Clin Orthop Relat Res. 2017 Jan;475(1):94-105. doi: 10.1007/s11999-016-4931-z.
10
Liposomal bupivacaine for regional anesthesia.用于区域麻醉的脂质体布比卡因
Curr Opin Anaesthesiol. 2015 Oct;28(5):593-7. doi: 10.1097/ACO.0000000000000240.
引用本文的文献
1
Interscalene nerve block with plain bupivacaine versus liposomal bupivacaine for arthroscopic rotator cuff repair: A randomized controlled trial.用于关节镜下肩袖修复的普通布比卡因与脂质体布比卡因肌间沟神经阻滞：一项随机对照试验。
Saudi J Anaesth. 2025 Apr-Jun;19(2):243-250. doi: 10.4103/sja.sja_44_25. Epub 2025 Mar 25.
2
Use of bupivacaine liposomal injectable suspension in children aged 2 to 6 years undergoing cardiac surgery does not accelerate recovery.在接受心脏手术的2至6岁儿童中使用布比卡因脂质体注射用混悬液并不能加速恢复。
JTCVS Open. 2024 Dec 4;23:245-255. doi: 10.1016/j.xjon.2024.11.013. eCollection 2025 Feb.
3
Liposomal Bupivacaine in Peripheral Nerve Blocks: Duration and Meaningful Differences.脂质体布比卡因用于周围神经阻滞：持续时间及显著差异
Anesthesiology. 2024 Oct 1;141(4):638-642. doi: 10.1097/ALN.0000000000005133.
4
[Liposomal bupivacaine-No breakthrough in postoperative pain management].[脂质体布比卡因——术后疼痛管理无突破]
Anaesthesiologie. 2022 Jul;71(7):556-564. doi: 10.1007/s00101-022-01118-7. Epub 2022 Apr 25.
5
Feasibility and safety of same day subcutaneous defibrillator implantation and send home (DASH) strategy.同日皮下除颤器植入和出院（DASH）策略的可行性和安全性。
J Interv Card Electrophysiol. 2020 Mar;57(2):311-318. doi: 10.1007/s10840-019-00673-1. Epub 2019 Dec 7.
6
HTX-011 reduced pain intensity and opioid consumption versus bupivacaine HCl in herniorrhaphy: results from the phase 3 EPOCH 2 study.HTX-011 在疝修补术中相较于布比卡因盐酸盐降低了疼痛强度和阿片类药物的使用：来自 3 期 EPOCH 2 研究的结果。
Hernia. 2019 Dec;23(6):1071-1080. doi: 10.1007/s10029-019-02023-6. Epub 2019 Aug 19.
7
Use of Liposomal Bupivacaine for Postoperative Analgesia in an Incisional Pain Model in Rats ().脂质体布比卡因在大鼠切口痛模型中用于术后镇痛的研究（）
J Am Assoc Lab Anim Sci. 2017 Jan 1;56(1):63-68.
8
A Comparison of 4 Analgesic Regimens for Acute Postoperative Pain Control in Breast Augmentation Patients.乳房增大术患者术后急性疼痛控制的4种镇痛方案比较
Ann Plast Surg. 2017 Jun;78(6S Suppl 5):S299-S304. doi: 10.1097/SAP.0000000000001132.
本文引用的文献
1
Impact of local administration of liposome bupivacaine for postsurgical analgesia on wound healing: a review of data from ten prospective, controlled clinical studies.局部给予脂质体布比卡因用于术后镇痛对伤口愈合的影响：来自十项前瞻性、对照临床研究数据的综述。
Clin Ther. 2013 Mar;35(3):312-320.e5. doi: 10.1016/j.clinthera.2013.02.005. Epub 2013 Mar 1.
2
Liposomal bupivacaine: a review of a new bupivacaine formulation.脂质体布比卡因：一种新型布比卡因制剂的综述。
J Pain Res. 2012;5:257-64. doi: 10.2147/JPR.S27894. Epub 2012 Aug 14.
3
Liposomal bupivacaine: an innovative nonopioid local analgesic for the management of postsurgical pain.脂质体布比卡因：一种新型非阿片类局部镇痛药，用于治疗术后疼痛。
Pharmacotherapy. 2012 Sep;32(9 Suppl):19S-26S. doi: 10.1002/j.1875-9114.2012.01183.x.
4
Bupivacaine liposome injectable suspension compared with bupivacaine HCl for the reduction of opioid burden in the postsurgical setting.布比卡因脂质体注射悬浮液与盐酸布比卡因相比，可减少术后阿片类药物的使用。
Curr Med Res Opin. 2012 Oct;28(10):1609-15. doi: 10.1185/03007995.2012.721760. Epub 2012 Sep 3.
5
Efficacy profile of liposome bupivacaine, a novel formulation of bupivacaine for postsurgical analgesia.脂质体布比卡因的疗效概况，一种新型布比卡因制剂，用于术后镇痛。
J Pain Res. 2012;5:107-16. doi: 10.2147/JPR.S30861. Epub 2012 May 1.
6
Pharmacokinetic Compatibility Study of Lidocaine with EXPAREL in Yucatan Miniature Pigs.利多卡因与EXPAREL在尤卡坦小型猪体内的药代动力学相容性研究。
ISRN Pharm. 2011;2011:582351. doi: 10.5402/2011/582351. Epub 2011 Dec 27.
7
Perirectal block for out-patient anorectal surgery: a new technique.
Biomedica. 2011 Jun;31(2):196-9. doi: 10.1590/S0120-41572011000200006.
8
Bupivacaine extended-release liposome injection for prolonged postsurgical analgesia in patients undergoing hemorrhoidectomy: a multicenter, randomized, double-blind, placebo-controlled trial.布比卡因脂质体注射液用于肛肠痔术后长效镇痛的多中心随机双盲安慰剂对照临床试验
Dis Colon Rectum. 2011 Dec;54(12):1552-9. doi: 10.1097/DCR.0b013e318232d4c1.
9
A phase 3, randomized, placebo-controlled trial of DepoFoam® bupivacaine (extended-release bupivacaine local analgesic) in bunionectomy.一项 3 期、随机、安慰剂对照试验，评估 DepoFoam®布比卡因（布比卡因长效局部镇痛药）在拇囊炎切除术的应用。
Adv Ther. 2011 Sep;28(9):776-88. doi: 10.1007/s12325-011-0052-y. Epub 2011 Aug 12.
10
Pain outcomes: a brief review of instruments and techniques.疼痛结局：仪器与技术的简要综述
Curr Pain Headache Rep. 2009 Feb;13(1):39-43. doi: 10.1007/s11916-009-0009-x.
Zotero 插件