Agostinelli Claudio, Pileri Stefano
Section of Haematopathology, Department of Experimental, Diagnostic and Specialty Medicine - DIMES, University of Bologna, Italy.
Mediterr J Hematol Infect Dis. 2014 Jun 5;6(1):e2014040. doi: 10.4084/MJHID.2014.040. eCollection 2014.
Hodgkin's lymphoma is a lymphoid tumour that represents about 1% of all de novo neoplasms occurring every year worldwide. Its diagnosis is based on the identification of characteristic neoplastic cells within an inflammatory milieu. Molecular studies have shown that most, if not all cases, belong to the same clonal population, which is derived from peripheral B-cells. The relevance of Epstein-Barr virus infection at least in a proportion of patients was also demonstrated. The REAL/WHO classification recognizes a basic distinction between nodular lymphocyte predominance HL (NLPHL) and classic HL (CHL), reflecting the differences in clinical presentation, behavior, morphology, phenotype, molecular features as well as in the composition of their cellular background. CHL has been classified into four subtypes: lymphocyte rich, nodular sclerosing, mixed cellularity and lymphocyte depleted. Despite its well known histological and clinical features, Hodgkin's lymphoma (HL) has recently been the object of intense research activity, leading to a better understanding of its phenotype, molecular characteristics and possible mechanisms of lymphomagenesis.
霍奇金淋巴瘤是一种淋巴肿瘤，约占全球每年新发肿瘤的1%。其诊断基于在炎症环境中识别特征性肿瘤细胞。分子研究表明，即使不是所有病例，大多数都属于同一克隆群体，该群体源自外周B细胞。还证实了至少一部分患者中存在爱泼斯坦-巴尔病毒感染。REAL/WHO分类法认识到结节性淋巴细胞为主型HL（NLPHL）和经典型HL（CHL）之间的基本区别，这反映了临床表现、行为、形态、表型、分子特征以及细胞背景组成方面的差异。CHL已分为四种亚型：富于淋巴细胞型、结节硬化型、混合细胞型和淋巴细胞消减型。尽管霍奇金淋巴瘤（HL）具有众所周知的组织学和临床特征，但最近它一直是深入研究的对象，这使得人们对其表型、分子特征以及淋巴瘤发生的可能机制有了更好的理解。
