Fénichel P, Grimaldi M, Olivero J F, Donzeau M, Gillet J Y, Harter M
Department of Endocrinology and Diabetology, Hôpital de l'Archet, Nice, France.
Fertil Steril. 1989 May;51(5):845-9. doi: 10.1016/s0015-0282(16)60677-5.
Ovarian responses to stimulation for in vitro fertilization by clomiphene citrate menotropins have been correlated to the hormonal profiles determined during spontaneous cycles. The authors found 80% of high plasmatic luteinizing hormone (LH) and/or androgens levels associated with an inappropriated response: premature LH surge, multifollicular ovarian response, or dissociated cystic response, versus only 11% with appropriated responses. High plasmatic follicle-stimulating hormone existed in 71% of the no response group. Detryptoréline, a luteinizing hormone-releasing hormone agonist associated with menotropins, in a "short procedure" maintained the adequate responses and suppressed premature LH surges. The no response group was moderately improved, as were multifollicular and dissociated cystic response groups. Hormonal profiles could be useful predictive factors of the ovarian response for adaptation on the first procedure of stimulation.
氯米芬枸橼酸促性腺激素刺激卵巢用于体外受精的反应已与自然周期中测定的激素谱相关联。作者发现，80%的高血浆促黄体生成素（LH）和/或雄激素水平与不适当反应相关：LH过早峰、多卵泡卵巢反应或分离性囊性反应，而适当反应仅占11%。无反应组中71%存在高血浆促卵泡生成素。德曲瑞林，一种与促性腺激素相关的促黄体生成素释放激素激动剂，在“短方案”中维持了适当反应并抑制了LH过早峰。无反应组有适度改善，多卵泡和分离性囊性反应组也是如此。激素谱可能是刺激首次疗程适应性卵巢反应的有用预测因素。
