以叠氮化物和胺作为替代无金属催化剂的合成方法，通过间硝基卟啉的芳香亲核取代反应（S(N)Ar）来获得间位N-取代卟啉。

Aromatic nucleophilic substitution (S(N)Ar) of meso-nitroporphyrin with azide and amines as an alternative metal catalyst free synthetic approach to obtain meso-N-substituted porphyrins.

作者信息

Devillers Charles H, Hebié Seydou, Lucas Dominique, Cattey Hélène, Clément Sébastien, Richeter Sébastien

机构信息

Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR CNRS 6302, Université de Bourgogne , BP 47870, 21078 Dijon Cedex, France.

出版信息

J Org Chem. 2014 Jul 18;79(14):6424-34. doi: 10.1021/jo5005586. Epub 2014 Jul 2.

DOI:10.1021/jo5005586

PMID:24960068

Abstract

Aromatic nucleophilic substitution reaction of the nitro group of meso-nitroporphyrins with azide and various amines was achieved and represents an alternative procedure to C-N coupling reactions usually needed to obtain such meso-N-substituted porphyrins in good yields.

摘要

实现了中位硝基卟啉的硝基与叠氮化物及各种胺的芳环亲核取代反应，这是一种替代通常为高收率获得此类中位氮取代卟啉所需的碳氮偶联反应的方法。