生物活性底物还原1,2 - 二氧杂环丁烷过程中的单电子转移
Single-electron-transfer in the reduction of 1,2-dioxetanes by biologically active substrates.
作者信息
Adam W, Vargas F, Epe B, Schiffmann D, Wild D
机构信息
Institute of Organic Chemistry, University of Würzburg, F.R.G.
出版信息
Free Radic Res Commun. 1989;5(4-5):253-8. doi: 10.3109/10715768909074708.
PMID:2496009
Abstract
Substances of low oxidation potential, which can also make available protons and hydrogen atoms, e.g. phenothiazines, NADH, and ascorbic acid efficiently reduce 1,2-dioxetanes to their vic-diols by single-electron-transfer; a significant side reaction is catalytic decomposition of dioxetanes into the corresponding ketone fragments.
摘要
具有低氧化电位且能提供质子和氢原子的物质，如吩噻嗪、烟酰胺腺嘌呤二核苷酸（NADH）和抗坏血酸，可通过单电子转移有效地将1,2 - 二氧杂环丁烷还原为其邻二醇；一个重要的副反应是二氧杂环丁烷催化分解为相应的酮片段。
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