Robles-Osorio Maria Ludivina, Zacarías-Rangel Verónica, García-Solís Pablo, Hernández-Montiel Hebert Luis, Solís Juan Carlos, Sabath Ernesto
Facultad de Ciencias Naturales. Universidad Autónoma de Querétaro.
Rev Invest Clin. 2014 Mar-Apr;66(2):113-20.
OBJECTIVE. To examine the prevalence of abnormal thyroid function tests and positive anti-thyroid antibodies in two Central Mexican cities. MATERIAL AND METHODS. Subjects 18 to 70 years old were randomly selected to participate in this survey. A questionnaire was given and blood samples were taken to measure TSH and free T4 levels as well as anti-TPO and anti- Tg antibodies. RESULTS. The mean TSH level in subjects without existing thyroid disease was 1.72 mIU/L; 0.64 and 3.74 mIU/L were the 2.5th and 97.5th percentiles. The mean free T4 level was 1.02 ng/dL, and the 2.5th and 97.5th percentiles were 0.78 and 1.31 ng/dL, respectively. There was a 2.5% prevalence of former diagnosed thyroid diseases, 3.9% of individuals were sub-hypo, and 1.1% had overt hypothyroidism. Total hypothyroidism prevalence was 7.48% (when we considered TSH levels greater than 4.5 mIU/L), but it was 11.03% when diagnosed with TSH values greater than 3.5 mIU/L. Factors associated with hypothyroidism were older age, positive family background of thyroid disease, and positive anti- TPO and anti-Tg antibodies. Subclinical and overt hyperthyroidism were found in 1.7% of participants. CONCLUSIONS. Abnormal thyroid function test prevalence in this population was high, but few participants were aware of having a thyroid disease. The prevalence of positive anti-thyroid antibodies was high. More studies are necessary to elucidate the effects of thyroid abnormalities on other aspects of health status and quality of life.
目的。研究墨西哥中部两个城市甲状腺功能检查异常及抗甲状腺抗体阳性的患病率。材料与方法。随机选取18至70岁的受试者参与本调查。发放问卷并采集血样，检测促甲状腺激素（TSH）和游离甲状腺素（T4）水平以及抗甲状腺过氧化物酶（anti-TPO）和抗甲状腺球蛋白（anti-Tg）抗体。结果。无现存甲状腺疾病的受试者TSH平均水平为1.72 mIU/L；第2.5百分位数和第97.5百分位数分别为0.64和3.74 mIU/L。游离T4平均水平为1.02 ng/dL，第2.5百分位数和第97.5百分位数分别为0.78和1.31 ng/dL。既往诊断为甲状腺疾病的患病率为2.5%，亚临床甲减者占3.9%，临床甲减者占1.1%。总的甲减患病率为7.48%（当TSH水平大于4.5 mIU/L时），但当TSH值大于3.5 mIU/L时诊断，患病率为11.03%。与甲减相关的因素包括年龄较大、甲状腺疾病家族史阳性以及anti-TPO和anti-Tg抗体阳性。1.7%的参与者存在亚临床甲亢和临床甲亢。结论。该人群甲状腺功能检查异常的患病率较高，但很少有参与者意识到自己患有甲状腺疾病。抗甲状腺抗体阳性的患病率较高。需要更多研究来阐明甲状腺异常对健康状况和生活质量其他方面的影响。
