Salem E A, Hegazy M M, El Khouley E A
Department of Public Health and Community Medicine, Faculty of Medicine, University of Menoufiya, Menoufiya, Egypt.
Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, University of Menoufiya, Menoufiya, Egypt.
East Mediterr Health J. 2014 Jun 18;20(6):363-71.
In view of the widespread use of pesticides in Egypt and the increasing incidence of leukaemia and lymphoma we aimed to assess pesticide exposure and other selected variables as risk factors for lymphoproliferative disorders (leukaemia and non-Hodgkin lymphoma). In a hospital-based, retrospective, case-control study in 2011-2012, adult cases of lymphoproliferative disorders (n = 130) were recruited from outpatient clinics in Menoufia, Egypt, while controls (n = 130) were age- and sex-matched fracture patients. Family history of cancer, exposure to X-rays, smoking and use of hair dyes were not risk factors for lymphoproliferative disorders in univariate analysis. History of exposure to pesticides and HCV infection were significant risk factors for lymphoproliferative disorders in multivariate analysis (OR = 2.24; 95% CI: 1.22-4.11 and OR = 2.67; 95% CI: 1.50-4.80 respectively). The risk was significant for cases of non-Hodgkin lymphoma but not chronic lymphocytic leukaemia.
鉴于农药在埃及广泛使用，且白血病和淋巴瘤的发病率不断上升，我们旨在评估农药暴露及其他选定变量作为淋巴增生性疾病（白血病和非霍奇金淋巴瘤）的风险因素。在2011 - 2012年一项基于医院的回顾性病例对照研究中，淋巴增生性疾病的成年病例（n = 130）从埃及米努夫省的门诊诊所招募，而对照组（n = 130）为年龄和性别匹配的骨折患者。在单因素分析中，癌症家族史、X射线暴露、吸烟和使用染发剂并非淋巴增生性疾病的风险因素。在多因素分析中，农药暴露史和丙型肝炎病毒感染是淋巴增生性疾病的显著风险因素（OR = 2.24；95% CI：1.22 - 4.11和OR = 2.67；95% CI：1.50 - 4.80）。该风险在非霍奇金淋巴瘤病例中显著，但在慢性淋巴细胞白血病病例中不显著。
