Marone J, Patel S, Page M, Cheriyath P
Medical Director of Research, Harrisburg Hospital, Harrisburg, Pennsylvania, USA.
J Surg Case Rep. 2012 Sep 1;2012(9):3. doi: 10.1093/jscr/2012.9.3.
Signet cell carcinomas of the colon are well documented in the adult population, but this cancer incidence is very low in the adolescent population. A 17 year old male child presented with one month of progressive abdominal pain. CT scan of the abdomen showed significant abnormality involving the ascending colon characterized as marked mural thickening. Biopsy results indicated signet ring cell carcinoma. Signet cell carcinoma is presumed to be caused by genetic mutations just like the other colorectal cancers. Treatment for signet cell carcinoma is the same as other colorectal cancer. Surgery is part of the standard management of patients with colon and rectal cancer stages I, II and III. Signet cell cancer has a poor survival with the median survival period of about 9 months. The incidence among adolescence is much lower than that of the adult population.
结肠印戒细胞癌在成年人群中有充分的文献记载,但在青少年人群中这种癌症的发病率非常低。一名17岁男童出现了一个月的进行性腹痛。腹部CT扫描显示升结肠有明显异常,表现为显著的肠壁增厚。活检结果表明为印戒细胞癌。与其他结直肠癌一样,印戒细胞癌据推测是由基因突变引起的。印戒细胞癌的治疗方法与其他结直肠癌相同。手术是I、II和III期结肠癌和直肠癌患者标准治疗的一部分。印戒细胞癌的生存率很低,中位生存期约为9个月。青少年中的发病率远低于成年人群。