[5'-肌苷酸脱氢酶的基本功能及其在药物研发中的应用]

[The basic functions of inosine 5'-monophosphate dehydrogenase and its application in drug discovery].

作者信息

Zhang You-Wen, Zhang Dan, Sun Hua

出版信息

Yao Xue Xue Bao. 2014 Mar;49(3):285-92.

Abstract

Inosine 5'-monophosphate dehydrogenase (IMPDH) is a key enzyme of de novo GMP biosynthesis. The expression and activity of IMPDH can be affected by diseases and physiological process. It is the drug target for anticancer, antiviral, antimicrobial and immunosuppressive therapeutics. Not only catalytic action but the other biological functions of IMPDH also play an important role in diseases. The basic functions, mechanism of catalysis, classification of inhibitors, biological functions and the latest advances to IMPDH will be illustrated in this review. It is expected to be helpful to the discovery of new inhibitors and biological functions of IMPDH.

摘要

肌苷5'-单磷酸脱氢酶（IMPDH）是从头合成鸟苷酸的关键酶。IMPDH的表达和活性会受到疾病和生理过程的影响。它是抗癌、抗病毒、抗微生物和免疫抑制治疗的药物靶点。IMPDH不仅其催化作用，其他生物学功能在疾病中也发挥着重要作用。本文将阐述IMPDH的基本功能、催化机制、抑制剂分类、生物学功能及最新研究进展。期望对发现IMPDH新的抑制剂及生物学功能有所帮助。