Nair Vasu, Shu Qingning
The Center for Drug Discovery, Department of Pharmaceutical and Biomedical Sciences, The University of Georgia, Athens, GA, USA.
Antivir Chem Chemother. 2007;18(5):245-58. doi: 10.1177/095632020701800501.
Inosine monophosphate (IMP) dehydrogenase (IMPDH) is a significant enzyme in the purine nucleotide biosynthetic pathway. IMPDH is viewed as an important biological target in the quest for drugs in the antiviral therapeutic area. This review article is focused on the chemistry and biology of IMPDH inhibitors and the use of IMPDH inhibition data as a probe in antiviral drug discovery. Examples of both inosine 5' monophosphate and NAD+ site-directed inhibitors are presented. Correlation of antiviral activities with IMPDH inhibition is discussed.
肌苷一磷酸（IMP）脱氢酶（IMPDH）是嘌呤核苷酸生物合成途径中的一种重要酶。在抗病毒治疗领域寻找药物的过程中，IMPDH被视为一个重要的生物学靶点。这篇综述文章聚焦于IMPDH抑制剂的化学和生物学特性，以及将IMPDH抑制数据用作抗病毒药物发现中的一种探针。文中展示了肌苷5'-单磷酸和NAD⁺位点定向抑制剂的实例。还讨论了抗病毒活性与IMPDH抑制之间的相关性。
