伏隔核体积与青少年司法涉案青少年的饮酒频率有关。
Nucleus Accumbens Volume Is Associated with Frequency of Alcohol Use among Juvenile Justice-Involved Adolescents.
机构信息
Department of Psychology and Neuroscience, University of Colorado Boulder, Muenzinger D244, UCB 345, Boulder, CO 80309-0345, USA.
Department of Psychology, University of New Mexico, MSC03 2220, Albuquerque, NM 87131-0001, USA.
出版信息
Brain Sci. 2012 Nov 12;2(4):605-18. doi: 10.3390/brainsci2040605.
Differential neural development of structures associated with reward and control systems may underlie risky behavior in adolescence. The nucleus accumbens and orbitofrontal cortex (OFC) have been implicated in substance use behavior, although structural studies have yet to explore specific relationships between nucleus accumbens and OFC volumes and alcohol use in adolescence. High resolution structural MRI scans and assessments of recent alcohol use and lifetime substance use were collected in a sample of 168 juvenile justice-involved adolescents to explore whether gray matter volumes were associated with past 3-month quantity and frequency of alcohol use. Gray matter volumes were not associated with average quantity of alcohol use. Accumbens volume was positively associated with past 3-month frequency of drinking, and OFC volume was negatively associated with drinking frequency. Results may suggest that structural differences in regions related to reward and control processing may contribute to risk behavior in adolescence.
与奖励和控制系统相关的结构的差异神经发育可能是青少年冒险行为的基础。伏隔核和眶额皮层（OFC）与物质使用行为有关，尽管结构研究尚未探索伏隔核和 OFC 体积与青少年时期酒精使用之间的具体关系。在一个 168 名参与少年司法的青少年样本中收集了高分辨率结构 MRI 扫描以及最近的酒精使用和终生物质使用评估，以探讨灰质体积是否与过去 3 个月的酒精使用量和频率有关。灰质体积与平均酒精使用量无关。伏隔核体积与过去 3 个月的饮酒频率呈正相关，而 OFC 体积与饮酒频率呈负相关。结果可能表明，与奖励和控制处理相关的区域的结构差异可能导致青少年时期的风险行为。
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