Cusick C G, Wall J T, Felleman D J, Kaas J H
Department of Psychology, Vanderbilt University, Nashville, Tennessee 37240.
J Comp Neurol. 1989 Apr 8;282(2):169-90. doi: 10.1002/cne.902820203.
Multiunit microelectrode recordings and injections of horseradish peroxidase (HRP) were used to reveal neuron response properties, somatotopic organization, and interconnections of somatosensory cortex in the lateral sulcus (sylvian fissure) of New World owl monkeys. There were a number of main findings. 1) Representations of the face and head in areas 3b, 1, and S-II are found on the upper bank of the lateral sulcus. Most of the mouth and lip representations of area 3b were found in a rostral extension along the lip of the lateral sulcus. Adjacent cortex deeper in the lateral sulcus represented the nose, eye, ear, and scalp. 2) S-II was located on the upper bank of the lateral sulcus and extended past the fundus onto the deepest part of the lower bank. The face was represented most superficially in the sulcus, with the hand, foot, and trunk located in a rostrocaudal sequence deeper in the sulcus. The orientation of S-II is "erect," with the limbs pointing away from area 3b. 3) Neurons in S-II were activated by light tactile stimulation of the contralateral body surface. Receptive fields were several times larger than for area 3b neurons. 4) A 1-2-mm strip of cortex separating the face and hand representations in S-II was consistently responsive to the stimulation of deep receptors but was unresponsive to light cutaneous stimulation. 5) Injections of horseradish peroxidase in the electrophysiologically identified hand or foot representations of area 3b revealed somatotopically matched interconnections with mapped hand and foot representations in S-II. 6) A systematic representation of the body, termed the "ventral somatic" area, VS, was found extending laterally from S-II on the lower bank of the lateral sulcus. Within VS, the hand and foot were represented deep in the sulcus along the hand and foot regions of S-II, and the face was lateral near the ventral lip of the sulcus. 7) Neurons at most recording sites in the VS region were activated by contralateral cutaneous stimuli. However, a few sites had neurons with bilateral receptive fields. Receptive field sizes were comparable to those in S-II. In addition, neurons in islands of cortex in the VS region had properties that suggested that they were activated by pacinian receptors, while other regions were difficult to activate by light tactile stimuli but responded to stimuli that would activate deep receptors. 8) A few recording sites caudal to S-II on the upper bank of the lateral sulcus were responsive to somatic stimuli.(ABSTRACT TRUNCATED AT 400 WORDS)
采用多单元微电极记录法和辣根过氧化物酶（HRP）注射法，以揭示新大陆猫头鹰猴外侧沟（西尔维厄斯裂）体感皮层的神经元反应特性、躯体定位组织及相互连接。有多项主要发现。1）3b区、1区和S-II区中面部和头部的表征位于外侧沟的上壁。3b区中大部分口和唇的表征位于沿外侧沟唇缘的嘴侧延伸处。外侧沟更深部位的相邻皮层代表鼻子、眼睛、耳朵和头皮。2）S-II区位于外侧沟的上壁，并延伸至沟底以外，直至下壁的最深部位。面部在沟中最浅表处被表征，手、脚和躯干则按嘴尾顺序位于沟中更深部位。S-II区的方位是“直立”的，四肢远离3b区。3）S-II区的神经元通过对侧身体表面的轻触觉刺激而被激活。感受野比3b区神经元的感受野大几倍。4）在S-II区中分隔面部和手部表征的一条1 - 2毫米宽的皮层条带，对深部感受器的刺激始终有反应，但对轻皮肤刺激无反应。5）在电生理确定的3b区手部或足部表征中注射辣根过氧化物酶，揭示了与S-II区中映射的手部和足部表征存在躯体定位匹配的相互连接。6）发现一个称为“腹侧躯体”区（VS）的身体系统性表征，从外侧沟下壁的S-II区横向延伸。在VS区内，手和脚在沟中沿着S-II区的手和脚区域位于深部，而面部在沟腹侧唇附近位于外侧。7）VS区大多数记录位点的神经元通过对侧皮肤刺激而被激活。然而，有少数位点的神经元具有双侧感受野。感受野大小与S-II区的相当。此外，VS区皮层岛中的神经元具有的特性表明它们由帕西尼小体感受器激活，而其他区域难以被轻触觉刺激激活，但对能激活深部感受器的刺激有反应。8）在外侧沟上壁S-II区尾侧的少数记录位点对躯体刺激有反应。（摘要截于400字）
