Department of Oncology, Second Affiliated Hospital of Nanchang University, Minde Road 1, Nanchang, Jiangxi 330006, China.
Dis Markers. 2014;2014:710915. doi: 10.1155/2014/710915. Epub 2014 May 19.
Inflammatory bowel disease (IBD) is a chronic disease mostly involved with intestine with unknown etiology. Diagnosis, evaluation of severity, and prognosis are still present as challenges for physicians. An ideal biomarker with the characters such as simple, easy to perform, noninvasive or microinvasive, cheap, rapid, and reproducible is helpful for patients and clinicians. Currently biomarkers applied in clinic include CRP, ESR, pANCA, ASCA, and fecal calprotectin. However, they are far from ideal. Lots of studies are focused on seeking for ideal biomarker for IBD. Herein, the paper reviewed recent researches on biomarkers of IBD to get advances of biomarkers in inflammatory bowel disease.
炎症性肠病(IBD)是一种主要累及肠道的慢性疾病,病因不明。诊断、严重程度评估和预后仍然是医生面临的挑战。具有简单、易于操作、非侵入性或微创性、廉价、快速和可重复性等特点的理想生物标志物有助于患者和临床医生。目前应用于临床的生物标志物包括 CRP、ESR、pANCA、ASCA 和粪便钙卫蛋白。然而,它们远非理想。许多研究都致力于寻找理想的 IBD 生物标志物。本文综述了 IBD 生物标志物的最新研究进展,以期了解炎症性肠病生物标志物的研究进展。