自身免疫反应在牙周病中的作用。
Role of autoimmune responses in periodontal disease.
作者信息
Nair Soumya, Faizuddin Mohamed, Dharmapalan Jayanthi
机构信息
Om Dental Clinic, No. 1554, Hebbal 2nd Stage, Mysore 570017, India.
M.R. Ambedkar Dental College and Hospital, No. 1/37, Cline Road, Cooke Town, Bangalore 560005, India.
出版信息
Autoimmune Dis. 2014;2014:596824. doi: 10.1155/2014/596824. Epub 2014 May 25.
Periodontal diseases are characterized by localized infections and inflammatory conditions that directly affect teeth supporting structures which are the major cause of tooth loss. Several studies have demonstrated the involvement of autoimmune responses in periodontal disease. Evidences of involvement of immunopathology have been reported in periodontal disease. Bacteria in the dental plaque induce antibody formation. Autoreactive T cells, natural killer cells, ANCA, heat shock proteins, autoantibodies, and genetic factors are reported to have an important role in the autoimmune component of periodontal disease. The present review describes the involvement of autoimmune responses in periodontal diseases and also the mechanisms underlying these responses. This review is an attempt to throw light on the etiopathogenesis of periodontal disease highlighting the autoimmunity aspect of the etiopathogenesis involved in the initiation and progression of the disease. However, further clinical trials are required to strengthen the role of autoimmunity as a cause of periodontal disease.
牙周疾病的特征是局部感染和炎症，直接影响牙齿的支持结构，而这是牙齿脱落的主要原因。多项研究表明自身免疫反应参与了牙周疾病。已有报道称免疫病理学参与了牙周疾病。牙菌斑中的细菌会诱导抗体形成。据报道，自身反应性T细胞、自然杀伤细胞、抗中性粒细胞胞浆抗体、热休克蛋白、自身抗体和遗传因素在牙周疾病的自身免疫成分中起重要作用。本综述描述了自身免疫反应在牙周疾病中的参与情况以及这些反应的潜在机制。本综述旨在阐明牙周疾病的病因发病机制，突出疾病发生和发展过程中病因发病机制的自身免疫方面。然而，需要进一步的临床试验来强化自身免疫作为牙周疾病病因的作用。
Zotero 插件