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脱发与牙周炎:探寻其间的关联

Alopecia and Periodontitis: Exploring the connecting dots.

作者信息

Agrawal Jaya, Lal Nand, Singhal Rameshwari

机构信息

Department of Periodontology, Faculty of Dental Sciences, King George's Medical University, Lucknow, Uttar Pradesh, India.

出版信息

J Indian Soc Periodontol. 2023 May-Jun;27(3):233-237. doi: 10.4103/jisp.jisp_114_22. Epub 2023 May 1.

DOI:10.4103/jisp.jisp_114_22
PMID:37346853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10281310/
Abstract

Alopecia areata is a systemic disease with nonscarring hair loss from the scalp, face, or any part of the body. The disease with undetermined etiology and pathogenesis has a considerable impact on the social life of patients which gradually builds up stress and expedites further deterioration of their condition. Interestingly, in such patients, besides stress-relieving exercises and immunomodulators, well-timed dental assessment and prompt treatment have contributed to improving the prognosis of alopecia. This depicts an interrelationship between alopecia and oral foci of infections. Over the past few decades, periodontitis has remained to be one of the predominant forms of oral focus of infection for systemic diseases. The present review throws light on the role of stress and autoimmunity in establishing a possible correlation between alopecia and periodontitis. It is augmented with documented case reports, demanding a complete oral examination in patients with the unexplained origin of alopecia. An interdisciplinary approach is the need of the hour which can prevent the progression of both the diseases as well as other oral infections.

摘要

斑秃是一种全身性疾病,表现为头皮、面部或身体任何部位的非瘢痕性脱发。这种病因和发病机制尚未明确的疾病对患者的社交生活有相当大的影响,会逐渐增加压力并加速病情进一步恶化。有趣的是,在这类患者中,除了减压锻炼和免疫调节剂外,适时的牙科评估和及时治疗有助于改善斑秃的预后。这表明了斑秃与口腔感染病灶之间的相互关系。在过去几十年里,牙周炎一直是全身性疾病口腔感染病灶的主要形式之一。本综述揭示了压力和自身免疫在斑秃与牙周炎之间建立可能关联中的作用。文中还补充了病例报告,要求对斑秃病因不明的患者进行全面的口腔检查。目前迫切需要一种跨学科方法,以防止这两种疾病以及其他口腔感染的进展。

相似文献

1
Alopecia and Periodontitis: Exploring the connecting dots.脱发与牙周炎:探寻其间的关联
J Indian Soc Periodontol. 2023 May-Jun;27(3):233-237. doi: 10.4103/jisp.jisp_114_22. Epub 2023 May 1.
2
[Janus kinase inhibitors for the treatment of alopecia areata].用于治疗斑秃的Janus激酶抑制剂
Hautarzt. 2022 May;73(5):336-343. doi: 10.1007/s00105-022-04982-x. Epub 2022 Apr 28.
3
The autoimmune basis of alopecia areata: a comprehensive review.斑秃的自身免疫基础:全面综述。
Autoimmun Rev. 2015 Feb;14(2):81-9. doi: 10.1016/j.autrev.2014.10.014. Epub 2014 Oct 12.
4
Alopecia areata: A multifactorial autoimmune condition.斑秃:一种多因素自身免疫性疾病。
J Autoimmun. 2019 Mar;98:74-85. doi: 10.1016/j.jaut.2018.12.001. Epub 2018 Dec 15.
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Childhood Alopecia Areata: An Overview of Treatment and Recent Patents.儿童斑秃:治疗概述及近期专利。
Recent Pat Inflamm Allergy Drug Discov. 2020;14(2):117-132. doi: 10.2174/1872213X14999200728145822.
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Trichotillomania: Bizzare Patern of Hair Loss at 11-Year-old Girl.拔毛癖:一名11岁女孩的怪异脱发模式。
Acta Dermatovenerol Croat. 2016 Jun;24(2):150-3.
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Co-localization of alopecia areata and lichen planopilaris in a patient receiving immunosuppressants: A rare case.一名接受免疫抑制剂治疗的患者斑秃与扁平苔藓样毛发角化病的共定位:1例罕见病例
J Cosmet Dermatol. 2021 Mar;20(3):976-979. doi: 10.1111/jocd.13600. Epub 2020 Jul 24.
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Alopecia areata: Disease characteristics, clinical evaluation, and new perspectives on pathogenesis.斑秃:疾病特征、临床评估及发病机制的新观点。
J Am Acad Dermatol. 2018 Jan;78(1):1-12. doi: 10.1016/j.jaad.2017.04.1141.
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Alopecia areata of dental origin.牙源性斑秃
Med Oral. 2002 Jul-Oct;7(4):303-8.
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Hair and Nail Conditions: Alopecia Evaluation.毛发与指甲病症:脱发评估
FP Essent. 2022 Jun;517:11-16.

本文引用的文献

1
Impact of the global burden of periodontal diseases on health, nutrition and wellbeing of mankind: A call for global action.牙周病对人类健康、营养和福祉的全球负担的影响:呼吁全球行动。
J Clin Periodontol. 2017 May;44(5):456-462. doi: 10.1111/jcpe.12732. Epub 2017 May 8.
2
Role of autoimmune responses in periodontal disease.自身免疫反应在牙周病中的作用。
Autoimmune Dis. 2014;2014:596824. doi: 10.1155/2014/596824. Epub 2014 May 25.
3
Lifetime incidence risk of alopecia areata estimated at 2.1% by Rochester Epidemiology Project, 1990-2009.
罗切斯特流行病学项目估计,1990年至2009年期间斑秃的终生发病风险为2.1%。
J Invest Dermatol. 2014 Apr;134(4):1141-1142. doi: 10.1038/jid.2013.464. Epub 2013 Nov 11.
4
Periodontal disease: linking the primary inflammation to bone loss.牙周病:将原发性炎症与骨质流失联系起来。
Clin Dev Immunol. 2013;2013:503754. doi: 10.1155/2013/503754. Epub 2013 May 23.
5
Psychological stress, vascular inflammation, and atherogenesis: potential roles of circulating cytokines.心理应激、血管炎症与动脉粥样硬化形成:循环细胞因子的潜在作用
J Cardiovasc Pharmacol. 2013 Jul;62(1):6-12. doi: 10.1097/FJC.0b013e3182858fac.
6
Prevalence of periodontitis in the Indian population: A literature review.印度人群中牙周炎的患病率:文献综述。
J Indian Soc Periodontol. 2011 Jan;15(1):29-34. doi: 10.4103/0972-124X.82261.
7
Comorbidity profiles among patients with alopecia areata: the importance of onset age, a nationwide population-based study.斑秃患者的合并症特征:发病年龄的重要性——一项全国范围内基于人群的研究。
J Am Acad Dermatol. 2011 Nov;65(5):949-56. doi: 10.1016/j.jaad.2010.08.032. Epub 2011 May 25.
8
Dentistry and internal medicine: from the focal infection theory to the periodontal medicine concept.牙科学与内科学:从病灶感染理论到牙周病医学概念。
Eur J Intern Med. 2010 Dec;21(6):496-502. doi: 10.1016/j.ejim.2010.07.011.
9
Hair follicles from alopecia areata patients exhibit alterations in immune privilege-associated gene expression in advance of hair loss.斑秃患者的毛囊在脱发之前就表现出免疫赦免相关基因表达的改变。
J Invest Dermatol. 2010 Nov;130(11):2677-80. doi: 10.1038/jid.2010.180. Epub 2010 Jul 8.
10
Transcriptional profiling in alopecia areata defines immune and cell cycle control related genes within disease-specific signatures.斑秃中基因转录谱的研究定义了疾病特异性特征内与免疫和细胞周期控制相关的基因。
Genomics. 2010 Sep;96(3):146-53. doi: 10.1016/j.ygeno.2010.05.002. Epub 2010 May 28.