Sennari Goh, Hirose Tomoyasu, Iwatsuki Masato, Ōmura Satoshi, Sunazuka Toshiaki
Graduate School of Infection Control Sciences, Kitasato University, Japan.
Chem Commun (Camb). 2014 Aug 14;50(63):8715-8. doi: 10.1039/c4cc03134b. Epub 2014 Jun 25.
Efficient and practical total synthesis of puberulic acid has been accomplished via 8 steps, with 54% overall yield, and only two C-C bond formations, without the introduction of oxygen atoms into the core skeleton. Construction of the tropolone framework as the key transformation was achieved by multi-tandem oxidation of the aliphatic-triol, from D-(+)-galactose as the starting material.
