Bhojgude Sachin Suresh, Thangaraj Manikandan, Suresh Eringathodi, Biju Akkattu T
Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune 411008, India.
Org Lett. 2014 Jul 3;16(13):3576-9. doi: 10.1021/ol501579d. Epub 2014 Jun 25.
The reaction of arynes with indene/benzofurans has been developed. The arynes were generated from 2-(trimethylsilyl)aryl triflates by the fluoride-induced 1,2-elimination react with indene or various benzofurans proceeding via a cascade reaction involving the Diels-Alder reaction and a [2 + 2] cycloaddition reaction. The tandem process afforded functionalized dihydrobenzocyclobutaphenanthrenes in moderate to good yields. Moreover, the method has been utilized for the one-pot synthesis of benzo[b]fluoranthene.
已开发出芳炔与茚/苯并呋喃的反应。芳炔由2-(三甲基甲硅烷基)芳基三氟甲磺酸酯通过氟化物诱导的1,2-消除反应生成，与茚或各种苯并呋喃反应，通过涉及狄尔斯-阿尔德反应和[2 + 2]环加成反应的串联反应进行。该串联过程以中等至良好的产率提供了功能化的二氢苯并环丁并菲。此外，该方法已用于苯并[b]荧蒽的一锅合成。
