Ren Jie, Wu Qin, Wang Yuejiao, Liu Jie, Yang Xiaoguang, Yang Lichen
Wei Sheng Yan Jiu. 2014 May;43(3):357-60, 377.
To study gender differences in different measures of iron status in infants aged 4 and 6 months old.
Term delivery pregnant women with normal iron status were recruit with informed consent. Infants with normal birth weight were selected and exclusive breastfeeding were required. All infants were randomly assigned into one control group and one iron supplement group at 4 months old. The latter group were given a daily dose of iron supplement corresponding to 1 mg/kg body weight of elemental iron from 4 to 6 month. At 4 and 6 months old, vein blood were sampled to analyze hemoglobin (Hb), mean cell volume (MCV), serum ferritin (SF), and soluble transferrin receptors (sTfR) and the growth indices were measured.
Data of infants at 4 months old (n = 178) and 6 months old (n = 85) were collected. At 4 months old, male infants had significantly lower MCV and SF and higher sTfR, male infants had lower Hb but with no significant difference. 6 months old, the trends of differences stayed the same as at 4 months old, and MCV remained significant.
Male infants may have a higher risk to develop iron deficiency. Male infants may have a higher risk to develop iron deficiency. There needs to be respective diagnostical cut-off values and dietary iron requirement for male and female infants. At the same time, correct feeding is necessary.
研究4个月和6个月大婴儿铁状态不同指标的性别差异。
招募铁状态正常的足月分娩孕妇并获得其知情同意。选取出生体重正常的婴儿，要求纯母乳喂养。所有婴儿在4个月大时随机分为一个对照组和一个铁补充组。后一组在4至6个月期间每天给予相当于1毫克/千克体重元素铁的铁补充剂。在4个月和6个月大时，采集静脉血分析血红蛋白（Hb）、平均红细胞体积（MCV）、血清铁蛋白（SF）和可溶性转铁蛋白受体（sTfR），并测量生长指标。
收集了4个月大婴儿（n = 178）和6个月大婴儿（n = 85）的数据。4个月大时，男婴的MCV和SF显著较低，sTfR较高，男婴的Hb较低但无显著差异。6个月大时，差异趋势与4个月大时相同，且MCV仍有显著差异。
男婴发生缺铁的风险可能更高。男婴发生缺铁的风险可能更高。需要针对男婴和女婴分别设定诊断临界值和膳食铁需求量。同时，正确喂养很有必要。
