Utaida Sugunya, Auparakkitanon Saranya, Wilairat Prapon
Southeast Asian J Trop Med Public Health. 2014 Jan;45(1):1-5.
Although morbidity and mortality from malaria have steadily decreased worldwide, the ever present menace of the appearance of Plasmodium falciparum resistant to all antimalarials in current use, including most recently to artemisinin and its analogs, is of utmost concern, especially when development of new and affordable antimalarials has not kept abreast of this phenomenon. An alternative approach is to identify synergistic drug combinations, which would allow employment of otherwise non-efficacious antimalarial drugs. This study demonstrates that combinations of the chemical oxidant hydrogen hydroxide with antimalarial antibiotics targeting parasite mitochondrial and apicoplast ribosomes, which normally produce 'delayed-death' of parasites, act synergistically to inhibit P. falciparum growth in culture.
尽管全球疟疾的发病率和死亡率一直在稳步下降，但目前使用的所有抗疟药，包括最近对青蒿素及其类似物产生耐药性的恶性疟原虫的出现，这种一直存在的威胁令人极为担忧，特别是在新型且价格合理的抗疟药研发未能跟上这一现象的情况下。另一种方法是确定协同药物组合，这将允许使用原本无效的抗疟药物。本研究表明，化学氧化剂氢氧化氢与靶向寄生虫线粒体和顶质体核糖体的抗疟抗生素组合，通常会导致寄生虫“延迟死亡”，它们协同作用以抑制体外培养的恶性疟原虫生长。
