Powerski Maciej Janusz, Scheurig-Münkler Christian, Hamm Bernd, Gebauer Bernhard
Department of Radiology and Nuclear Medicine, Otto-von-Guericke University, Magdeburg, Germany.
J Med Imaging Radiat Oncol. 2014 Aug;58(4):472-80. doi: 10.1111/1754-9485.12187. Epub 2014 Jun 25.
To evaluate the uptake of the liver-specific magnetic resonance imaging (MRI) contrast agent gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) by functional liver parenchyma after radioembolisation (RE) of hepatic malignancies.
Uptake of Gd-EOB-DTPA prior to RE versus 60+/-24d and 126+/-32d after RE was compared in a group of 33 patients with primary or secondary hepatic malignancies. In patients who underwent single-lobe treatment, left and right lobes were compared 59+/-24 days after RE. Gd-EOB-DTPA uptake was determined as follows: ratio of mean signal intensity in liver parenchyma to muscle in Gd-EOB-DTPA-enhanced T1-weighted MRI was subtracted from ratio of mean intensity in liver parenchyma to muscle in unenhanced T1-weighted MRI.
Gd-EOB-DTPA uptake in liver parenchyma was 0.845+/-0.29 before RE, 0.615+/-0.38 (P = 0.0022) at day 60+/-24, and 0.739+/-0.30 at day 126+/-32 after RE. In cases of single-lobe treatment, Gd-EOB-DTPA uptake was 0.581+/-0.256 for treated and 0.828+/-0.32 (P = 0.0164) for untreated hepatic lobes.
Uptake of Gd-EOB-DTPA by liver parenchyma is impaired after RE, indicating dysfunction of the local hepatic system. These findings suggest that Gd-EOB-DTPA-enhanced MRI has the potential to be used for monitoring liver damage after RE.
评估肝恶性肿瘤放射性栓塞（RE）后功能性肝实质对肝脏特异性磁共振成像（MRI）造影剂钆乙氧基苄基二乙烯三胺五乙酸（Gd-EOB-DTPA）的摄取情况。
在一组33例原发性或继发性肝恶性肿瘤患者中，比较RE前与RE后60±24天和126±32天Gd-EOB-DTPA的摄取情况。在接受单叶治疗的患者中，于RE后59±24天比较左叶和右叶。Gd-EOB-DTPA摄取情况按以下方法确定：在Gd-EOB-DTPA增强的T1加权MRI中，肝实质平均信号强度与肌肉平均信号强度之比减去未增强的T1加权MRI中肝实质平均强度与肌肉平均强度之比。
RE前肝实质中Gd-EOB-DTPA摄取量为0.845±0.29，RE后60±24天时为0.615±0.38（P = 0.0022），RE后126±32天时为0.739±0.30。在单叶治疗的病例中，治疗叶的Gd-EOB-DTPA摄取量为0.581±0.256，未治疗叶为0.828±0.32（P = 0.0164）。
RE后肝实质对Gd-EOB-DTPA的摄取受损，表明局部肝脏系统功能障碍。这些发现提示Gd-EOB-DTPA增强MRI有潜力用于监测RE后的肝损伤。
