Department of Chemistry, Yale University, 225 Prospect Street, New Haven, CT 06520-8107 (USA).
Angew Chem Int Ed Engl. 2014 Jul 21;53(30):7892-5. doi: 10.1002/anie.201404320. Epub 2014 Jun 25.
Anti-Markovnikov alkyne hydration provides a valuable route to aldehydes. Half-sandwich ruthenium complexes ligated by 5,5'-bis(trifluoromethyl)-2,2'-bipyridine are remarkably active for this transformation. In the presence of 2 mol % metal, a wide range of functionalized aliphatic and aromatic alkynes are hydrated in high yield at ambient temperature.
反马氏规则炔烃水合反应为醛类的合成提供了一条很有价值的途径。由 5,5'-双（三氟甲基）-2,2'-联吡啶配体所稳定的半夹心型钌络合物在该转化中表现出极高的催化活性。在 2 mol%金属的存在下，一系列官能化的脂肪族和芳香族炔烃在环境温度下以高产率实现水合。
