Ito Shigemi, Tase Toru, Satoh Kennichi, Ueki Miyuki, Sato Ikuro, Sasano Hironobu
Department of Pathology, Miyagi Cancer Center, Natori, Japan.
Pathol Int. 2014 Jun;64(6):283-8. doi: 10.1111/pin.12173.
In this report, unique endocervical glandular lesions exhibiting gastric differentiation were examined in a patient with Peutz-Jeghers syndrome. The result of the human papillomavirus (HPV) in situ hybridization (ISH) for the hysterectomy specimens was negative, but they demonstrated a papillary mucinous adenocarcinoma at the proximal endocervix continuous to atypical lobular endocervical glandular hyperplasia. Both contained MUC6-positive neutral mucin in cytoplasm, and showed different immunoreactivity to p16, Ki-67, and p53. Moreover, they harbored the identical K-RAS gene mutation suggesting that there was a common origin. Somatic K-RAS mutation and defective function of p16 may have been involved in the tumorigenesis of these unusual mucinous neoplasms.
在本报告中，对一名患有黑斑息肉综合征患者的具有胃分化特征的独特子宫颈管腺性病变进行了检查。子宫切除标本的人乳头瘤病毒（HPV）原位杂交（ISH）结果为阴性，但在子宫颈近端显示出与非典型小叶状子宫颈管腺性增生连续的乳头状黏液腺癌。两者在细胞质中均含有MUC6阳性中性黏液，并且对p16、Ki-67和p53显示出不同的免疫反应性。此外，它们具有相同的K-RAS基因突变，提示存在共同起源。体细胞K-RAS突变和p16功能缺陷可能参与了这些不寻常黏液性肿瘤的发生。
