Weber Waldemar, Andersson Jan T
Institute of Inorganic and Analytical Chemistry, University of Muenster, Corrensstrasse 30, 48149, Muenster, Germany.
Anal Bioanal Chem. 2014 Sep;406(22):5347-58. doi: 10.1007/s00216-014-7972-8. Epub 2014 Jun 26.
The separation properties of six novel stationary phases for gas chromatography, commercially available from Sigma-Aldrich (Supelco) and based on ionic liquids (ILs), were investigated. The linear solvation energy relationship model (LSER) was used to describe the molecular interactions between these stationary phases and 30 solutes. The solutes belong to different groups of compounds, like haloalkanes, alcohols, ketones, aromatics, aliphatics, and others. A good description of different interactions, as described by the LSER model, could be achieved. The calculated values of system constants for the ionic liquid phases were compared with constants of commonly used standard phases like a 5 % phenyl/95 % dimethyl siloxane and a polyethylene glycol phase. The solute descriptors are in good agreement with those found by previous authors who have used the LSER model for 44 different ionic liquids as stationary phase. The experiments were carried out at two temperatures to evaluate the influence on the phase parameters and separation characteristics. The interactions of different functional groups with the IL phases are discussed. These novel IL phases are a promising replacement of or an addition to common polar phases. Based on the evaluated phase properties, several possibilities for applications of these novel phases are shown.
研究了西格玛奥德里奇公司（Supelco）市售的六种基于离子液体（ILs）的新型气相色谱固定相的分离性能。采用线性溶剂化能关系模型（LSER）描述这些固定相与30种溶质之间的分子相互作用。这些溶质属于不同的化合物组，如卤代烷、醇、酮、芳烃、脂肪族等。通过LSER模型可以很好地描述不同的相互作用。将离子液体相的系统常数计算值与常用标准相（如5%苯基/95%二甲基硅氧烷和聚乙二醇相）的常数进行了比较。溶质描述符与先前使用LSER模型将44种不同离子液体作为固定相的作者所发现的结果高度一致。在两个温度下进行实验，以评估对相参数和分离特性的影响。讨论了不同官能团与离子液体相的相互作用。这些新型离子液体相有望替代或补充常见的极性相。基于评估的相性质，展示了这些新型相的几种应用可能性。
