HIV感染早期的抑制性抗逆转录病毒疗法与胼胝体的可测量变化有关。
Early suppressive antiretroviral therapy in HIV infection is associated with measurable changes in the corpus callosum.
作者信息
Kelly Sean G, Taiwo Babafemi O, Wu Ying, Bhatia Ramona, Kettering Casey S, Gao Yi, Li Suyang, Hutten Ryan, Ragin Ann B
机构信息
Department of Internal Medicine, Feinberg School of Medicine, Northwestern University, 251 East Huron Street, Galter Pavilion Suite 3-150, Chicago, IL, 60611, USA.
出版信息
J Neurovirol. 2014 Oct;20(5):514-20. doi: 10.1007/s13365-014-0261-7. Epub 2014 Jun 26.
Abstract
The purpose of this study was to examine the impact of early suppressive antiretroviral therapy (ART) on brain structure and neurocognitive outcomes. We conducted an observational study of subjects within 1 year of HIV infection. Ten ART-naïve and 10 ART-suppressed individuals were matched for age and infection duration and age-matched to 10 HIV-seronegative controls. Quantitative brain imaging and neurocognitive data were analyzed. Subjects on suppressive ART had diminished corpus callosum structural integrity on macromolecular and microstructural imaging, higher cerebrospinal fluid percent, higher depression scores, and lower functional performance. Early suppressive ART may alter the trajectory of neurological progression of HIV infection, particularly in the corpus callosum.
摘要
本研究的目的是探讨早期抑制性抗逆转录病毒疗法（ART）对脑结构和神经认知结果的影响。我们对HIV感染1年内的受试者进行了一项观察性研究。将10名未接受过ART治疗的个体和10名接受ART抑制治疗的个体按年龄和感染持续时间进行匹配，并与10名年龄匹配的HIV血清阴性对照者进行匹配。对定量脑成像和神经认知数据进行了分析。接受抑制性ART治疗的受试者在大分子和微观结构成像上胼胝体结构完整性降低、脑脊液百分比更高、抑郁评分更高且功能表现更低。早期抑制性ART可能会改变HIV感染的神经学进展轨迹，尤其是在胼胝体方面。
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