一项基于全国人群队列研究中的前列腺癌与全身振动职业暴露情况
Prostate cancer and occupational exposure to whole-body vibration in a national population-based cohort study.
作者信息
Jones Marcella K, Harris M Anne, Peters Paul A, Tjepkema Michael, Demers Paul A
机构信息
Occupational Cancer Research Centre, Toronto, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.
出版信息
Am J Ind Med. 2014 Aug;57(8):896-905. doi: 10.1002/ajim.22354. Epub 2014 Jun 25.
BACKGROUND
Following preliminary evidence from observational studies, we test the potential relationship between whole-body vibration (WBV) and prostate cancer in a cohort study.
METHODS
WBV exposure was assigned based on occupation in 1991 and 1,107,700 participants were followed for incident prostate cancer until the end of 2003. Adjusted hazard rate ratios (HRs) were calculated using Cox proportional hazards modeling.
RESULTS
17,922 incident prostate cancer cases were observed. WBV-exposed men in Natural and Applied Sciences Occupations had a 37% elevated risk of prostate cancer (95% CI 1.09-1.72) and WBV-exposed men in Trades, Transport, and Equipment Operators Occupations had a 9% reduced risk (95% CI 0.86-0.97). Independent of WBV exposure, small but significant differences in risk were seen for several occupational categories.
CONCLUSIONS
We found no consistent relationship between WBV and prostate cancer. Further research could focus on other exposures or specific occupations in the studied categories to determine what may be contributing to the observed differences in prostate cancer risk.
背景
基于观察性研究的初步证据，我们在一项队列研究中检验全身振动（WBV）与前列腺癌之间的潜在关系。
方法
根据1991年的职业情况确定WBV暴露情况，对1107700名参与者进行随访，观察其前列腺癌发病情况直至2003年底。使用Cox比例风险模型计算调整后的风险率比值（HRs）。
结果
观察到17922例前列腺癌发病病例。从事自然科学和应用科学职业且暴露于WBV的男性患前列腺癌的风险升高37%（95%CI 1.09 - 1.72），而从事贸易、运输和设备操作职业且暴露于WBV的男性患前列腺癌的风险降低9%（95%CI 0.86 - 0.97）。独立于WBV暴露，在几个职业类别中观察到风险存在小但显著的差异。
结论
我们发现WBV与前列腺癌之间不存在一致的关系。进一步的研究可以聚焦于所研究类别中的其他暴露因素或特定职业，以确定哪些因素可能导致观察到的前列腺癌风险差异。
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