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儿童阑尾类癌肿瘤:对较保守手术的意义?

Appendiceal carcinoid tumor in children: implications for less radical surgery?

作者信息

Malkan A D, Wahid F N, Fernandez-Pineda I, Sandoval J A

机构信息

Department of Surgery, St. Jude Children's Research Hospital, MS 133, Room D3045, 262 Danny Thomas Place, Memphis, TN, 38105-3678, USA,

出版信息

Clin Transl Oncol. 2015 Mar;17(3):197-200. doi: 10.1007/s12094-014-1196-4. Epub 2014 Jun 26.

DOI:10.1007/s12094-014-1196-4
PMID:24965691
Abstract

The discovery of an appendiceal carcinoid tumor found incidentally or during the course of diagnostic or therapeutic procedures is a burden to both the patient and clinician. The role of the correct surgical operation is paramount for lesions suspected to be malignant. In the pediatric population, appendiceal carcinoids continue to challenge the clinician in choosing the optimal treatment when lesions are larger than 2 cm or involve the appendical base. While the criteria used to define these distinct lesions are available in most cases, the management and treatment are still debated and controversial when considering more radical surgical intervention. The purpose of this article is to give an overview regarding the history, diagnosis, histopathology, management, and controversies associated with appendiceal carcinoid in the pediatric population.

摘要

偶然发现或在诊断或治疗过程中发现阑尾类癌肿瘤,这对患者和临床医生来说都是一种负担。对于疑似恶性的病变,正确的外科手术作用至关重要。在儿科人群中,当阑尾类癌病变大于2厘米或累及阑尾根部时,在选择最佳治疗方案方面,仍然给临床医生带来挑战。虽然在大多数情况下可获得用于定义这些不同病变的标准,但在考虑更激进的外科干预时,其管理和治疗仍存在争议。本文旨在概述儿科人群中与阑尾类癌相关的病史、诊断、组织病理学、管理及争议。

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1
Appendiceal carcinoid tumor in children: implications for less radical surgery?儿童阑尾类癌肿瘤:对较保守手术的意义?
Clin Transl Oncol. 2015 Mar;17(3):197-200. doi: 10.1007/s12094-014-1196-4. Epub 2014 Jun 26.
2
Management of pediatric appendiceal carcinoid: a single institution experience from 5000 appendectomies.小儿阑尾类癌的管理:来自5000例阑尾切除术的单机构经验。
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The Problem of Appendiceal Carcinoids.阑尾类癌问题。
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[Appendiceal carcinoid tumors. Evaluation of long-term outcomes in a tertiary level].[阑尾类癌肿瘤。三级医疗机构长期预后评估]
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Delayed Detection of a Carcinoid Tumor after Conservative Therapy for Appendicitis in a 13-Year-Old Boy and a 17-Year-Old Girl.一名13岁男孩和一名17岁女孩阑尾炎保守治疗后类癌肿瘤的延迟检测
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本文引用的文献

1
EGFR, KRAS, BRAF-mutations and microsatellite instability are absent in goblet cell carcinoids of the appendix.阑尾杯状细胞类癌不存在表皮生长因子受体(EGFR)、 Kirsten 大鼠肉瘤病毒癌基因(KRAS)、B-Raf原癌基因(BRAF)突变以及微卫星不稳定性。
Pathol Res Pract. 2014 May;210(5):274-8. doi: 10.1016/j.prp.2014.01.002. Epub 2014 Jan 31.
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Appendix carcinoids in childhood: long-term experience at a single institution in Western Canada and systematic review.儿童阑尾类癌:加拿大西部一家机构的长期经验及系统评价
Pediatr Int. 2013 Apr;55(2):157-62. doi: 10.1111/ped.12047.
3
The perforated appendiceal carcinoid in children: a surgical dilemma.
小儿胃肠胰神经内分泌肿瘤:一例病例报告及文献综述
Medicine (Baltimore). 2019 Sep;98(37):e17154. doi: 10.1097/MD.0000000000017154.
4
Management and outcome of children with neuroendocrine tumors of the appendix in Spain: Is there room for improvement?西班牙阑尾神经内分泌肿瘤患儿的管理和结局:是否有改进的空间?
Clin Transl Oncol. 2017 Sep;19(9):1168-1172. doi: 10.1007/s12094-017-1653-y. Epub 2017 Mar 28.
儿童阑尾类癌穿孔:手术困境。
J Pediatr Surg. 2012 Jun;47(6):1155-8. doi: 10.1016/j.jpedsurg.2012.04.014.
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Carcinoid tumors of the appendix: a population-based study.阑尾类癌肿瘤:一项基于人群的研究。
J Surg Oncol. 2011 Jul 1;104(1):41-4. doi: 10.1002/jso.21888. Epub 2011 Feb 3.
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Epithelial neoplasms of the appendix.阑尾上皮性肿瘤。
Arch Pathol Lab Med. 2010 Nov;134(11):1612-20. doi: 10.5858/2010-0073-CCR.1.
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Appendiceal carcinoid tumor with lymph node metastasis in a child: case report and review of the literature.儿童阑尾类癌伴淋巴结转移 1 例报告并文献复习
J Pediatr Surg. 2010 Nov;45(11):e1-5. doi: 10.1016/j.jpedsurg.2010.07.025.
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Carcinoid tumors of the appendix in children: experience from a tertiary center in northern Greece.儿童阑尾类癌肿瘤:来自希腊北部一家三级中心的经验。
J Pediatr Gastroenterol Nutr. 2010 Nov;51(5):622-5. doi: 10.1097/MPG.0b013e3181e05358.
8
The NANETS consensus guideline for the diagnosis and management of neuroendocrine tumors: well-differentiated neuroendocrine tumors of the Jejunum, Ileum, Appendix, and Cecum.NANETS 共识指南:用于诊断和治疗神经内分泌肿瘤——空肠、回肠、阑尾和盲肠的神经内分泌肿瘤。
Pancreas. 2010 Aug;39(6):753-66. doi: 10.1097/MPA.0b013e3181ebb2a5.
9
The pathologic classification of neuroendocrine tumors: a review of nomenclature, grading, and staging systems.神经内分泌肿瘤的病理学分类:命名法、分级和分期系统综述。
Pancreas. 2010 Aug;39(6):707-12. doi: 10.1097/MPA.0b013e3181ec124e.
10
Combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix.阑尾类癌的一种新形态学变异型:经典类癌与杯状细胞类癌的联合肿瘤。
Am J Surg Pathol. 2010 Aug;34(8):1163-7. doi: 10.1097/PAS.0b013e3181e52916.