Division of Kidney Diseases and Hypertension, Rhode Island Hospital, APC 9, 593 Eddy St., Providence, RI, 02906, USA,
Curr Diab Rep. 2014 Aug;14(8):516. doi: 10.1007/s11892-014-0516-y.
Resistant hypertension in diabetes is associated with poor cardiovascular and renal outcomes. This brief review will examine the definitions and epidemiology of resistant hypertension and consider the differences between apparent resistant hypertension and truly resistant or refractory hypertension. It will review the role of the sympathetic nervous system in resistant hypertension. It will consider the relationship between obesity and leptin resistance and sympathetic signaling; the role of obstructive sleep apnea in resistant hypertension; and the role of aldosterone in resistant hypertension. It will conclude by mentioning briefly renal nerve ablation.
糖尿病患者的高血压耐药与心血管和肾脏不良结局相关。这篇简要综述将探讨高血压耐药的定义和流行病学，并考虑表观性高血压耐药和真正的耐药或难治性高血压之间的区别。文中将回顾交感神经系统在高血压耐药中的作用，讨论肥胖和瘦素抵抗与交感信号之间的关系、阻塞性睡眠呼吸暂停在高血压耐药中的作用，以及醛固酮在高血压耐药中的作用。最后将简要提及肾神经消融术。
